# US 11,897,886 B2 · Pyrazolo[4,3-d]pyrimidines as antitumor agents

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- Number: US 11,897,886 B2
- Document ID: US11897886B2
- Status: Granted
- Kind: B2
- Application number: 16/949,519
- Filed: 2020-11-02
- Published: 2021-08-12
- Granted: 2024-02-13
- Earliest claimed: 2018-03-07
- Assignees: Duquesne University of the Holy Spirit
- Applicants: Duquesne University of the Holy Spirit
- Inventors: Aleem Gangjee
- Web page: https://patentgrep.com/patent/US11897886B2

## CPC

- C07D 487/04: Ortho-condensed systems
- A61P 35/00: Antineoplastic agents
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound of Formula II, or optionally a salt or a hydrate of the compound of Formula II is provided: wherein R1 is selected from the group consisting of a hydrogen, an alkyl group having from one to six carbon atoms, an aryl group, and a heteroaryl group; R2 is selected from the group consisting of an alkyl group having from one to six carbon atoms, a hydrogen, a NRaRb group wherein Ra is either a hydrogen or an alkyl group having from one to six carbon atoms and Rb is either a hydrogen or an alkyl group having from one to six carbon atoms, an aryl group, a heteroaryl group, and a halogen; R is an alkyl group having from one to six carbon atoms; and Ar is selected from the group consisting of an alkyl group having from one to six carbon atoms, a substituted aryl, and a substituted heteroaryl.

## Claims

### Claim 1

A compound of Formula II:
wherein R1 is selected from the group consisting of a hydrogen, an alkyl group having from one to six carbon atoms, an aryl group, and a heteroaryl group; R2 is either a methyl group or NH2; R is an alkyl group having from one to six carbon atoms; and Ar is selected from the group consisting of an alkyl group having from one to six carbon atoms, a substituted aryl, and a substituted heteroaryl.