US 11,897,859 B1 · Coumarin compounds as antibacterial agents

Abstract

The coumarin compounds are antibacterial agents. The emergence of drug-resistant bacteria calls for constant development of new antibacterial agents with the aim of generating medicaments that are potent against drug sensitive and resistant bacteria and are well tolerated. The present compounds are not only new, but have very valuable antimicrobial properties. These compounds showed a broad spectrum of activity against gram-positive and gram-negative bacteria, as well tuberculosis mycobacteria. They also showed potent activity against drug-resistant bacteria, such as MRSA and VRSA. The molecular target of these compounds was identified as DNA Gyrase B. Based on their pharmacological profiles, the present compounds may find important clinical applications for severe infectious diseases and tuberculosis.

Claims11

Dependent claims

A method of treating a bacterial infection in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula I:

or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
the —NHR1 group is present at the 6- or 7-position of the compound;
R1 is —COR5;
R5 is selected from the group consisting of methyl and ethyl;
A is a phenyl ring;
and
R2, R3, and R4 are independently a hydrogen atom, —COR9 where R9 is a hydroxy group, a trifluoromethoxy group, a trifluoromethyl group, a hydroxy group, —OR6 where R6 is methyl, or a methylamino group substituted with a methyl and a cyclohexyl group;
and
wherein at least one of R2 and R3 and R4 is not hydrogen.

6 more elements

Dependencies are inferred from the claim text.

Coumarin compounds as antibacterial agents

Life of this patent

Coumarin compounds as antibacterial agents

Life of this patent

Abstract

Claims11