# US 11,897,855 B1 · Antioxidant vitamin C derivative

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- Number: US 11,897,855 B1
- Document ID: US11897855B1
- Status: Granted
- Kind: B1
- Application number: 18/220,739
- Filed: 2023-07-11
- Granted: 2024-02-13
- Earliest claimed: 2023-07-11
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Imene Bayach; Amel Ibrahim; Nadeem Sadiq Sheikh; Khurshid Ayub
- Web page: https://patentgrep.com/patent/US11897855B1

## CPC

- C07D 307/33: in position 2, the oxygen atom being in its keto or unsubstituted enol form
- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 8/676: {Ascorbic acid, i.e. vitamin C}
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61Q 19/08: Anti-ageing preparations
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A structural modification of vitamin C designed to increase its antioxidant activity is provided. The approach involves the substitution of the hydroxyl group (OH) by fluorine (F) at position 4 of vitamin C, resulting in the formation of a new structure. Based on quantum calculations, this modification may enhance the antioxidant properties of vitamin C and its ability to scavenge free radicals.

## Claims

### Claim 1

A vitamin C derivative compound having the formula:

### Claim 2 (depends on 1)

The vitamin C derivative compound of claim 1, having a bond dissociation enthalpy (BDE) of about 87 kcal/mol.

### Claim 3 (depends on 1)

A pharmaceutical composition, comprising the vitamin C derivative compound of claim 1 and a pharmaceutically acceptable carrier.

### Claim 4 (depends on 1)

A cosmetic composition, comprising the vitamin C derivative compound of claim 1 and a cosmetically acceptable carrier.

### Claim 5 (depends on 3)

A method of promoting an antioxidant activity in a subject, the method comprising administering to a subject in need thereof the pharmaceutical composition of claim 3.

### Claim 6 (depends on 4)

A method of promoting an antioxidant activity in a subject, the method comprising administering to a subject in need thereof the cosmetic composition of claim 4.

### Claim 7 (depends on 3)

A method of promoting skin health in a subject, the method comprising administering to a subject in need thereof the pharmaceutical composition of claim 3.

### Claim 8 (depends on 4)

A method of promoting skin health in a subject, the method comprising administering to a subject in need thereof the cosmetic composition of claim 4.

### Claim 9 (depends on 3)

A method of protecting skin against oxidative damage in a subject, the method comprising administering to a subject in need thereof the pharmaceutical composition of claim 3.

### Claim 10 (depends on 4)

A method of protecting skin against oxidative damage in a subject, the method comprising administering to a subject in need thereof the cosmetic composition of claim 4.