# US 11,896,848 B2 · Methods for setup corrections in radiation therapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,896,848 B2 - Document ID: US11896848B2 - Status: Granted - Kind: B2 - Application number: 17/375,586 - Filed: 2021-07-14 - Published: 2021-11-04 - Granted: 2024-02-13 - Earliest claimed: 2019-01-16 - Assignees: RefleXion Medical, Inc. - Applicants: RefleXion Medical, Inc. - Inventors: Jayakrishnan Janardhanan; Michael Kirk Owens - Web page: https://patentgrep.com/patent/US11896848B2 ## CPC - A61N 5/1049: {for verifying the position of the patient with respect to the radiation beam} - A61N 5/103: {Treatment planning systems} - A61N 5/1031: {using a specific method of dose optimization} - A61N 5/1037: {taking into account the movement of the target, e.g. 4D-image based planning} - A61N 5/1039: {using functional images, e.g. PET or MRI} - A61N 5/1045: {using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT} - A61N 5/1047: {with movement of the radiation head during application of radiation, e.g. for intensity modulated arc therapy or IMAT} - A61N 5/1048: {Monitoring, verifying, controlling systems and methods} - A61N 5/1069: {Target adjustment, e.g. moving the patient support} - A61N 5/107: {in real time, i.e. during treatment} - A61N 5/1081: {Rotating beam systems with a specific mechanical construction, e.g. gantries} - A61N 5/1082: {having multiple beam rotation axes} - A61N 2005/1052: {using positron emission tomography [PET] single photon emission computer tomography [SPECT] imaging} - A61N 2005/1055: {using magnetic resonance imaging [MRI]} - A61N 2005/1061: {using an x-ray imaging system having a separate imaging source} - A61N 2005/1091: {Kilovoltage or orthovoltage range photons} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Disclosed herein are methods for patient setup and registration for the irradiation of target tissue regions. A method for positioning a patient for radiation therapy may include acquiring an image of a first patient target region and a second patient target region. A first set of patient position-shift vectors may be calculated based on the acquired image and a treatment planning image of the first patient target region. A second set of patient position-shift vectors may be calculated based on the acquired image, a treatment planning image of the second patient target region, and the first set of patient position-shift vectors. The patient may be positioned according to the first set of patient position-shift vectors in a first location. The patient may be moved to a second location and positioned according to the second set of patient position-shift vectors. ## Claims ### Claim 1 A method for positioning a patient for a radiation therapy, the method comprising: acquiring an image of a first patient target region and a second patient target region; calculating a first set of patient position-shift vectors based on the acquired image and a first treatment planning image of the first patient target region; calculating a second set of patient position-shift vectors based on the acquired image, a second treatment planning image of the second patient target region, and the first set of patient position-shift vectors; positioning the patient at a first location according to the first set of patient position-shift vectors; and positioning the patient at a second location according to the second set of patient position-shift vectors. ### Claim 2 (depends on 1) The method of claim 1, wherein positioning the patient at the first location according to the first set of patient position-shift vectors comprises moving a radiation therapy patient platform and/or a therapeutic radiation source according to the first set of patient position-shift vectors. ### Claim 3 (depends on 2) The method of claim 2, wherein moving the radiation therapy patient platform comprises moving the radiation therapy patient platform along its X-axis, and/or Y-axis, and/or Z-axis. ### Claim 4 (depends on 2) The method of claim 2, wherein moving the radiation therapy patient platform comprises adjusting a yaw and/or a pitch of the radition therapy patient platform and moving the therapeutic radiation source comprises adjusting a roll of a gantry to which the therapeutic radiation source is coupled. ### Claim 5 (depends on 1) The method of claim 1, wherein positioning the patient at the second location according to the second set of patient position-shift vectors comprises moving a radiation therapy patient platform according to the second set of patient position-shift vectors. ### Claim 6 (depends on 5) The method of claim 5, wherein positioning the patient at the second location according to the second set of patient position-shift vectors comprises moving a therapeutic radiation source according to the second set of patient position-shift vectors. ### Claim 7 (depends on 6) The method of claim 6, wherein moving the therapeutic radiation source according to the second set of patient position-shift vectors comprises adjusting a roll of a gantry to which the therapeutic radiation source is coupled. ### Claim 8 (depends on 5) The method of claim 5, wherein moving the radiation therapy patient platform according to the second set of patient position-shift vectors comprises adjusting a yaw and/or a pitch of the radition therapy patient platform. ### Claim 9 (depends on 1) The method of claim 1, wherein the first treatment planning image and the second treatment planning image are the same treatment planning image. ### Claim 10 (depends on 1) The method of claim 1, wherein the acquired image is a PET image. ### Claim 11 (depends on 1) The method of claim 1, wherein the acquired image is a CT image. ### Claim 12 (depends on 1) The method of claim 1, wherein calculating the first set of patient position-shift vectors and the second set of patient position-shift vectors occurs before a therapeutic radiation source is activated. ### Claim 13 (depends on 1) The method of claim 1, further comprising: calculating a first location difference by comparing a location of the first patient target region in the acquired image with a location of the first patient target region in the first treatment planning image; calculating a second location difference by comparing a location of the second patient target region in the acquired image with a location of the second patient target region in the second treatment planning image; and generating a notification if the first location difference or the second location difference exceeds a location difference threshold. ### Claim 14 (depends on 1) The method of claim 1, wherein the first patient target region and the second patient target region comprise one or more tumor regions. ### Claim 15 (depends on 14) The method of claim 14, wherein the first patient target region comprises a first portion of a tumor and the second patient target region comprises a second portion of the tumor. ### Claim 16 (depends on 1) The method of claim 1, wherein the first set of patient position-shift vectors and the second set of patient position-shift vectors comprise distance translations and direction translations. ### Claim 17 (depends on 16) The method of claim 16, wherein the direction translations comprise tilt angles. ### Claim 18 (depends on 1) The method of claim 1, wherein the first location is associated with a first beam station and the second location is associated with a second beam station adjacent to the first beam station.