# US 11,896,735 B2 · Ultrahigh ductility, novel Mg—Li based alloys for biomedical applications > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,896,735 B2 - Document ID: US11896735B2 - Status: Granted - Kind: B2 - Application number: 17/381,445 - Filed: 2021-07-21 - Published: 2021-12-02 - Granted: 2024-02-13 - Earliest claimed: 2014-12-12 - Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education - Applicants: University of Pittsburgh—of the Commonwealth System of Higher Education - Inventors: Prashant N. Kumta; Jingyao Wu; Oleg Velikokhatnyi - Web page: https://patentgrep.com/patent/US11896735B2 ## CPC - A61L 27/30: Inorganic materials - A61L 27/047: {Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06} - A61L 27/306: {Other specific inorganic materials not covered by A61L27/303 - A61L27/32} - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 31/022: {Metals or alloys} - A61L 31/082: {Inorganic materials} - A61L 31/088: {Other specific inorganic materials not covered by A61L31/084 or A61L31/086} - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - C22C 23/00: Alloys based on magnesium - A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - C22C: ALLOYS (treatment of alloys C21D, C22F) ## Abstract The invention includes compositions including magnesium-lithium alloys containing various alloying elements for medical implant devices. The devices are constructed of the compositions or have applied thereto a coating formed therefrom. Within the structure of the magnesium-lithium alloy, there is a co-existence of alpha and beta phases. The invention also includes methods of preparing the magnesium-lithium alloys and articles, such as medical implant devices, for use in medical applications, including orthopedic, dental, craniofacial and cardiovascular surgery. ## Claims ### Claim 1 A method for preparing a medical implant device, comprising: fabricating a substrate structured for implanting into a body, comprising: forming an alloy, comprising: I melting 9.00% by weight of lithium, 0.96% by weight of zinc, and 0.01% by weight of aluminum, and a remainder of magnesium based on the total weight of the alloy, or II melting about 8.99% by weight of lithium, 0.87% by weight of zinc, 1.07% by weight of aluminum, and a remainder of magnesium based on the total weight of the alloy, or III melting about 6.11% by weight of lithium, 0.92% by weight of zinc, 0.04% by weight of aluminum, and a remainder of magnesium based on the total weight of the alloy, wherein the alloy of I, II, or III is structured to exhibit a co-existence of alpha and beta phases, wherein the alloy of I, II, or III exhibits one or more of improved ductility and elasticity; casting the alloy of I, II, or III to form a casted alloy; and extruding the casted alloy to form the substrate in an extruded form. ### Claim 2 (depends on 1) The method of claim 1, wherein the melting step of I, II, or III further comprises one or more alloying elements selected from the group consisting of iron, zirconium, manganese, calcium, yttrium, rare earth elements, strontium, copper, silver, silicon, sodium, potassium and cerium. ### Claim 3 (depends on 1) The method of claim 1, further comprising adding an active agent to the alloy of I, II, or III. ### Claim 4 (depends on 1) The method of claim 1, further comprising using the medical implant device in orthopedic, dental, craniofacial and cardiovascular surgeries. ### Claim 5 (depends on 1) The method of claim 1, wherein the medical implant device releases lithium ions as a therapeutic drug eluting device. ### Claim 6 A method for preparing a medical implant device, comprising: fabricating a substrate structured for implanting into a body, comprising: forming an alloy, comprising: melting from about 5% by weight to about 11% by weight of lithium and a remainder of magnesium based on the total weight of the alloy, comprising: high energy mechanical alloying of the lithium and the magnesium; followed by uniaxial or isostatic compaction; and followed by sintering, wherein the alloy is structured to exhibit a co-existence of alpha and beta phases, and wherein the alloy exhibits one or more of improved ductility and elasticity; casting the alloy to form a casted alloy; and extruding the casted alloy to form the substrate in an extruded form. ### Claim 7 (depends on 1) The method of claim 1, wherein the melting step of I, II, or III comprises: high energy mechanical alloying of the lithium, the zinc, the aluminum, and the magnesium; followed by uniaxial or isostatic compaction; and followed by sintering.