# US 11,896,705 B2 · Functionalized polypeptides useful in hair treatment

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- Number: US 11,896,705 B2
- Document ID: US11896705B2
- Status: Granted
- Kind: B2
- Application number: 16/642,388
- Filed: 2018-08-24
- Published: 2020-06-18
- Granted: 2024-02-13
- Earliest claimed: 2017-08-30
- Assignees: UAB Ferentis; Ranjithkumar Ravichandran
- Applicants: Ferentis, UAB; Ranjithkumar Ravichandran
- Inventors: Jaywant Phopase; Ranjithkumar Ravichandran
- Web page: https://patentgrep.com/patent/US11896705B2

## CPC

- A61K 8/65: Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61Q 5/002: {Preparations for repairing the hair, e.g. hair cure}
- A61K 2800/82: Preparation or application process involves sonication or ultrasonication
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed is a polypeptide having a base amino acid sequence and wherein at least two amino acid residue side chains are substituted with functional Michael acceptor groups. Also disclosed are cosmetic compositions including the polypeptide, a method for repairing damaged hair using the polypeptide or composition, and to the use of the polypeptide or composition in such methods.

## Claims

### Claim 1

A cosmetic composition comprising a polypeptide for hair repair comprising:
a polypeptide base amino acid sequence (P), and
at least two amino acid residue side chains from the polypeptide base amino acid sequence (P),
wherein the at least two amino acid residue side chains are substituted with functional Michael acceptor groups,
wherein at least one of the at least two amino acid residue side chains has the Michael acceptor group (X) conjugated to the amino base of the amino acid residue (R), conforming to the following structure:
wherein the polypeptide base amino acid sequence (P) is from about 25 to about 1000 amino acids and is selected from the group consisting of: a natural protein or a fragment thereof and Gly-(Pro-Lys-Gly)4(Pro-Hyp-Gly)4(Asp-Hyp-Gly)4 or (Pro-Lys-Gly)4(Pro-Hyp-Gly)4(Asp-Hyp-Gly)4.

### Claim 2 (depends on 1)

The cosmetic composition according to claim 1, wherein at least one of the at least two amino acid residue side chains substituted with functional Michael acceptor groups comprises a carboxyl group.

### Claim 3 (depends on 2)

The cosmetic composition according to claim 2, wherein the at least two amino acid residues having side chains substituted with functional Michael acceptor groups are lysine residues.

### Claim 4 (depends on 2)

The cosmetic composition according to claim 2, wherein the polypeptide base amino acid sequence corresponds to an Extracellular matrix (ECM) protein or a fragment thereof.

### Claim 5 (depends on 1)

The cosmetic composition according to claim 1, wherein the at least two amino acid residues having side chains substituted with functional Michael acceptor groups are lysine residues.

### Claim 6 (depends on 2)

The cosmetic composition according to claim 2, wherein the polypeptide base amino acid sequence is Gly-(Pro-Lys-Gly)4(Pro-Hyp-Gly)4(Asp-Hyp-Gly)4, or (Pro-Lys-Gly)4(Pro-Hyp-Gly)4(Asp-Hyp-Gly)4, and wherein 2, 3, or 4 side chains of amino acid residues are substituted with functional Michael acceptor groups.

### Claim 7 (depends on 5)

The cosmetic composition according to claim 5, wherein the polypeptide base amino acid sequence corresponds to an Extracellular matrix (ECM) protein or a fragment thereof.

### Claim 8 (depends on 1)

The cosmetic composition according to claim 1, wherein the polypeptide base amino acid sequence corresponds to an Extracellular matrix (ECM) protein or a fragment thereof.

### Claim 9 (depends on 8)

The cosmetic composition according to claim 8, wherein the ECM protein is gelatin, keratin or collagen Type I, II, III or IV, or a fragment thereof.

### Claim 10 (depends on 1)

The cosmetic composition according to claim 1, wherein the polypeptide base amino acid sequence is Gly-(Pro-Lys-Gly)4(Pro-Hyp-Gly)4(Asp-Hyp-Gly)4 or (Pro-Lys-Gly)4(Pro-Hyp-Gly)4(Asp-Hyp-Gly)4, and wherein 2, 3, or 4 side chains of amino acid residues are substituted with functional Michael acceptor groups.

### Claim 11 (depends on 1)

The cosmetic composition according to claim 1, being an aqueous composition with a pH in the range 7.4-10.

### Claim 12 (depends on 1)

The cosmetic composition according to claim 1, comprising 1%-5% of the polypeptide.

### Claim 13 (depends on 1)

The cosmetic composition according to claim 1, further comprising a photoinitiator.

### Claim 14 (depends on 13)

Method for repair of damaged hair fibres, comprising bringing the cosmetic composition according to claim 13 in contact with the damaged hair fibres.

### Claim 15 (depends on 14)

Method according to claim 14, said method further comprising irradiating the damaged hair fibres with UV-light.