# US 11,896,696 B2 · Methods of skin whitening by use of canola extracts

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- Number: US 11,896,696 B2
- Document ID: US11896696B2
- Status: Granted
- Kind: B2
- Application number: 16/842,686
- Filed: 2020-04-07
- Published: 2020-12-24
- Granted: 2024-02-13
- Earliest claimed: 2013-01-31
- Assignees: 1242753 Ontario Inc.
- Applicants: 1242753 Ontario Inc.
- Inventors: Najla Guthrie; Robert Allen Guthrie
- Web page: https://patentgrep.com/patent/US11896696B2

## CPC

- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61P 17/00: Drugs for dermatological disorders
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Compositions and methods for lightening skin are provided. A method for lightening skin may include the step of identifying skin where lightening or whitening is desired and topically applying to the skin a composition including (a) a skin lightening agent comprising a canola extract and (b) a cosmetically acceptable carrier. A method for treating hyperpigmentation may include the step of identifying skin containing areas of hyperpigmentation and topically applying to the skin a composition including (a) a canola extract and (b) a cosmetically acceptable carrier.

## Claims

### Claim 1

A non-therapeutic method for lightening skin comprising the steps of:
identifying skin where lightening or whitening is desired; and
topically applying a topical formulation to the skin, the topical formulation comprising:
(a) a skin lightening agent comprising a canola extract, and
(b) a cosmetically acceptable carrier,
wherein the canola extract comprises protocatechuic acid, vanilic acid, caffeic acid, syringic acid, P-coumaric acid, and sinapic acid, and
wherein the canola extract provides from 0.1% to 5% sinapic acid by weight of the formulation; and
wherein the canola extract comprises a dose of phenolic acids present in a concentration between about 0.1 μg/ml and about 1000 μg/ml.

### Claim 2 (depends on 1)

The method of claim 1, wherein the canola extract further comprises a compound selected from the group consisting of a carotenoid, a tocopherol/sterol, a glucosinolate, and any combination thereof.

### Claim 3 (depends on 2)

The method of claim 2, wherein the canola extract comprises a glucosinolate selected from the group consisting of progoitrin, sinigrin, glucoraphanin, napoleferin, glucoalyssin, gluconapin, 4-hydroxybrassicin, glucobrassicanapin, glucobrassicin, gluconasturtin, 4-methoxy-glucobrassicin, neoglucobrassicin, and any combination thereof.

### Claim 4

A non-therapeutic method for treating hyperpigmentation comprising the steps of:
identifying skin containing areas of hyperpigmentation; and
topically applying a topical formulation to the skin, the topical formulation comprising:
(a) a canola extract, and
(b) a cosmetically acceptable carrier,
wherein the canola extract comprises protocatechuic acid, vanilic acid, caffeic acid, syringic acid, P-coumaric acid, and sinapic acid, and wherein the canola provides from 0.1% to 5% sinapic acid by weight of the formulation; and
wherein the canola extract comprises a dose of phenolic acids present in a concentration between about 0.1 μg/ml and about 1000 μg/ml.

### Claim 5 (depends on 4)

The method of claim 4, wherein the canola extract further comprises a compound selected from the group consisting of a carotenoid, a tocopherol/sterol, a glucosinolate, and any combination thereof.

### Claim 6 (depends on 5)

The method of claim 5, wherein the canola extract comprises a glucosinolate selected from the group consisting of progoitrin, sinigrin, glucoraphanin, napoleferin, glucoalyssin, gluconapin, 4-hydroxybrassicin, glucobrassicanapin, glucobrassicin, gluconasturtin, 4-methoxy-glucobrassicin, neoglucobrassicin, and any combination thereof.

### Claim 7 (depends on 1)

The method of claim 1, wherein the sinapic acid is in an amount of 0.236625% (w/w) in the canola extract.

### Claim 8 (depends on 1)

The method of claim 1, wherein the total of phenolic acids of protocatechuic acid, vanilic acid, caffeic acid, syringic acid, P-coumaric acid, and sinapic acid in the canola extract is 0.368902% (w/w).

### Claim 9 (depends on 1)

The method of claim 1, wherein the protocatechuic acid is in an amount of 0.019233% (w/w) in the canola extract.

### Claim 10 (depends on 1)

The method of claim 1, wherein the vanilic acid is in an amount of 0.009704% (w/w) in the canola extract.

### Claim 11 (depends on 1)

The method of claim 1, wherein the caffeic acid is in an amount of 0.0439% (w/w) in the canola extract.

### Claim 12 (depends on 1)

The method of claim 1, wherein the syringic acid is in an amount of 0.014985% (w/w) in the canola extract.

### Claim 13 (depends on 1)

The method of claim 1, wherein the P-coumaric acid is in an amount of 0.044455% (w/w) in the canola extract.

### Claim 14 (depends on 2)

The method of claim 2, wherein the canola extract further comprises a dose of tocopherol/sterol present in a concentration of between about 0.1 μg/ml and about 500 μg/ml.

### Claim 15 (depends on 2)

The method of claim 2, wherein the canola extract comprises a glucosinolate, and
wherein the canola extract comprises a dose of glucosinolates present in a concentration of between about 0.1 μg/ml to about 1000 μg/ml.