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US 11,896,663 B2Granted
Immunodeficiency virus type 1 (HIV-1) mutant envelope proteins
AssigneeJanssen Vaccines & Prevention B.V.
InventorsJohannes Petrus Maria Langedijk, Danielle Van Manen, Jort Vellinga, Frank Wegmann, Benoit Christophe Stephan Callendret, Anders Krarup, Jörn Stitz
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Abstract
Compositions and vaccine combinations containing synthetic HIV envelope proteins, and methods for inducing an immune response against human immunodeficiency virus (HIV) infection are described. Viral expression vectors encoding the synthetic HIV envelope proteins can be used in the vaccine combinations to induce immune responses against HIV and provide improved protective immunity against HIV.
Claims6
An RNA molecule encoding a synthetic HIV envelope protein comprising SEQ ID NO:
- 8, or SEQ ID NO:
- 8 having one or more mutations selected from the group consisting of (i) I529P, (ii) K480E, and (iii) a combination of EK479-48ORRRR, I529P, A471C and T575C.
Dependencies are inferred from the claim text.