Enhancing chemotherapy in medulloblastoma and glioblastoma with high basal p53 levels
AssigneeGeorgetown University
InventorsChristopher Albanese, Aisha Naeem
Life of this patent
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Abstract
Provided herein is a method of treating medulloblastoma or glioblastoma in a subject by administering to the subject a PI3K activator (e.g., thymosin β-4 or a derivative thereof) and one or more chemotherapeutic agents and/or radiation. The combination therapy is effective in the treatment of medulloblastoma or glioblastoma characterized by cells with elevated p53 levels.
Claims19
A method of treating a medulloblastoma subgroup selected from the group consisting of p53-mutated sonic hedgehog subgroup, MYC-p53 subgroup, and p53-positive subgroup in a subject comprising administering to the subject a chemotherapeutic agent and a PI3K activator.
Dependencies are inferred from the claim text.