# US 11,896,641 B2 · Peptide composition from early harvested rice and methods for slimming or promoting growth of probiotics using the same

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,896,641 B2
- Document ID: US11896641B2
- Status: Granted
- Kind: B2
- Application number: 17/519,583
- Filed: 2021-11-05
- Published: 2022-06-02
- Granted: 2024-02-13
- Earliest claimed: 2020-11-27
- Assignees: Tci Co., Ltd.
- Applicants: Tci Co., Ltd.
- Inventors: Yung-Hsiang Lin; Pei-Yi Wu
- Web page: https://patentgrep.com/patent/US11896641B2

## CPC

- A61K 36/899: Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K 38/08: Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)}
- A61K 38/10: Peptides having 12 to 20 amino acids {(A61K38/043 - A61K38/046 take precedence)}
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A peptide composition and methods for slimming and/or for promoting the growth of probiotics using early harvested rice prebiotics are provided. The peptide composition or the early harvested rice prebiotics includes at least one peptide as set forth in: SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 and SEQ, ID NO: 8.

## Claims

### Claim 1

A method for slimming and/or promoting probiotics growth, comprising administering to a subject in need thereof a composition comprising an effective dose of early harvested rice prebiotics, wherein the early harvested rice prebiotics comprise peptides as set forth in SEQ 1D NO: 1, SEQ 1D NO: 2, SEQ 1D NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 and SEQ ID NO: 8.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the early harvested rice prebiotics are prepared from early harvested rice, and the early harvested rice are rice seeds that are harvested within 15 to 25 days after flowering.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the early harvested rice prebiotics are prepared from the early harvested rice by aqueous extraction and hydrolysis with an alkaline protease.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the early harvested rice prebiotics are used to increase the content of leptin, adiponectin or glucose transporter type 4 (GLUT4) protein.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the early harvested rice prebiotics are used to increase the amounts of probiotics in human intestinal tract of the subject.

### Claim 6 (depends on 5)

The method according to claim 5, wherein the probiotics are Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus rhanmosus, Lactobacillus paracasei or Rhizopus bifidus.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the early harvested rice prebiotics are used to reduce body fat content in the subject.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the early harvested rice prebiotics are used to reduce waist circumference, trunk fat content, or leg fat content of the subject.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the early harvested rice prebiotics are used to reduce fasting blood glucose, fasting insulin or insulin resistance.

### Claim 10 (depends on 1)

The method according to claim 1, wherein the effective dose of the early harvested rice prebiotic is 500 mg.