# US 11,896,640 B2 · Composition for skin-whitening or preventing or improving skin wrinkles comprising green tea extract which has modified amounts of ingredients

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- Number: US 11,896,640 B2
- Document ID: US11896640B2
- Status: Granted
- Kind: B2
- Application number: 16/742,812
- Filed: 2020-01-14
- Published: 2020-07-16
- Granted: 2024-02-13
- Earliest claimed: 2019-01-15
- Assignees: Amorepacific Corporation
- Applicants: Amorepacific Corporation
- Inventors: Juewon Kim; Si Young Cho; Hyungsu Kim; Wonseok Park; Joonho Choi; Dong Hyun Kim; Jaewon You; Miyoung Park
- Web page: https://patentgrep.com/patent/US11896640B2

## CPC

- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 36/82: Theaceae (Tea family), e.g. camellia
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/782: Enzyme inhibitors; Enzyme antagonists
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed is to provide a composition for skin-whitening or preventing or improving skin wrinkles, comprising a green tea extract which has modified amounts of ingredients. More specifically, the extract and composition according to one aspect of the present disclosure are derived from natural plants that cause less irritation to the skin and are eco-friendly, thus they are safe, and thereby the extract and composition can exhibit excellent effects of effectively inhibiting melanin production and tyrosinase activity and preventing or improving skin whitening, and can exhibit excellent effects of effectively inhibiting the expression of MMP-1 and preventing or improving skin wrinkles.

## Claims

### Claim 1

A method for improving skin wrinkles, comprising:
administering, to an adult human subject in need thereof, a steam-processed green tea extract containing 4 to 15 wt. % of (−)-gallocatechin gallate (GCG) and 5.27 to 15 wt. % of (−)-epigallocatechin gallate (EGCG), on the basis of the total weight of the extract,
wherein the weight ratio of GCG:EGCG in the extract is 1:0.5 to 1:2,
wherein administering the green tea extract exhibits inhibition activity of MMP-1 (matrix metalloproteinase-1) of the human subject, and
wherein the total amount of EGCG, epigallocatechin (EGC), (−)epicatechin (EC), epicatechin 3-O-gallate (ECG), GCG, gallocatechin (GC), catechin (C) and catechin gallate (CG) in the extract are from 21 to 30 wt. %, on the basis of the total weight of the extract.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the extract is an extract obtained by extracting with one or more of water and C1 to C4 alcohol one or more times.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the green tea extract is formulated in a form of a composition, wherein the amount of the extract in the composition is from 1 wt. % to 100 wt. % relative to the total weight of the composition.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the dosage of the green tea extract is from 5 mg/kg/day to 1000 mg/kg/day.

### Claim 5 (depends on 1)

The method according to claim 1, wherein green tea extract is formulated in a form of a composition, wherein the composition is a food, pharmaceutical or cosmetic composition.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the skin wrinkles are caused by the reduction of elasticity of the dermal layer.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the steam-process is carried out for 1-7 hours.