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US 11,896,636 B2Granted
Immunogenic combination compositions and uses thereof
AssigneeGlaxosmithkline Biologicals SA
InventorsAndrew Geall, Ethan Settembre
Life of this patent
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Abstract
This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigens in two different forms—a first antigen from a pathogen, in RNA-coded form; and a second antigen from a different pathogen, in polypeptide form—are effective in inducing immune response to both pathogens.
Claims13
An immunogenic composition comprising:
- (i) a first polypeptide antigen derived from the group consisting of a viral pathogen and a bacterial pathogen, and
- (ii) a self-replicating RNA molecule encapsulated within a liposome, wherein said self-replicating RNA molecule cannot induce production of infectious viral particles, encodes a second polypeptide antigen from a viral pathogen, and can promote T cell-mediated immunity as well as humoral immunity to both first and second antigens,
- wherein said first and second antigens are antigens from different pathogens,
- wherein the self-replicating RNA molecule is not encapsulated in a virus-like particle;
- and
- wherein the liposome encapsulating the self-replicating RNA molecule does not include capsid protein or envelope glycoproteins.
3 more elements
An immunogenic composition comprising:
- (i) a first viral polypeptide antigen, and
- (ii) a self-replicating RNA molecule encapsulated within a liposome, wherein said self-replicating RNA molecule cannot induce production of infectious viral particles, encodes a second viral polypeptide antigen from a viral pathogen, and can promote T cell-mediated immunity as well as humoral immunity to both first and second antigens,
- wherein said first and second antigens are antigens from different viral pathogens,
- wherein one viral antigen is a Parvovirus antigen.
1 more element
An immunogenic composition comprising:
- (i) a Parvovirus polypeptide antigen, and (ii) a self-replicating RNA molecule that encodes a CMV polypeptide antigen.
Dependencies are inferred from the claim text.