# US 11,896,630 B2 · Composition for a formulated oral prebiotic edible composition

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- Number: US 11,896,630 B2
- Document ID: US11896630B2
- Status: Granted
- Kind: B2
- Application number: 17/376,237
- Filed: 2021-07-15
- Published: 2021-11-04
- Granted: 2024-02-13
- Earliest claimed: 2017-04-24
- Assignees: Knoze Jr. Corporation
- Applicants: Knoze Jr. Corporation
- Inventors: Shunsheng Han
- Web page: https://patentgrep.com/patent/US11896630B2

## CPC

- A61K 35/744: Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A23G 1/32: characterised by the composition {containing organic or inorganic compounds}
- A23G 1/36: characterised by the fats used (containing dairy products A23G1/46)
- A23G 1/40: characterised by the carbohydrates used, e.g. polysaccharides (containing dairy products A23G1/46)
- A23G 1/423: {containing microorganisms or enzymes}
- A23G 1/44: containing peptides or proteins (containing dairy products A23G1/46)
- A23G 1/48: containing plants or parts thereof, e.g. fruits, seeds or extracts (containing gums A23G1/40)
- A23G 3/36: characterised by the composition {containing organic or inorganic compounds}
- A23G 3/366: {containing microorganisms, enzymes}
- A23G 3/40: characterised by the fats used (containing dairy products A23G3/46)
- A23G 3/42: characterised by the carbohydrates used, e.g. polysaccharides (containing dairy products A23G3/46)
- A23G 3/44: containing peptides or proteins (containing dairy products A23G3/46)
- A23G 3/48: containing plants or parts thereof, e.g. fruits, seeds, extracts (containing gums A23G3/42)
- A23G 3/56: Products with edible or inedible supports, e.g. lollipops
- A23G 3/563: {products with an inedible support, e.g. a stick}
- A23L 21/25: Honey; Honey substitutes
- A23L 27/20: Synthetic spices, flavouring agents or condiments
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/12: Fatty acids or derivatives thereof
- A23L 33/125: containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates (indigestible substances A23L33/21)
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A23L 33/175: Amino acids
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/7004: Monosaccharides having only carbon, hydrogen and oxygen atoms
- A61K 31/7016: Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032)
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 35/644: Beeswax; Propolis; Royal jelly; Honey
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K 36/736: Prunus, e.g. plum, cherry, peach, apricot or almond
- A61K 36/898: Orchidaceae (Orchid family)
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14)
- A61K 47/46: Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
- A61P 11/02: Nasal agents, e.g. decongestants
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23G: COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A formulated oral prebiotic edible composition includes a free amino acid containing ingredient comprising L-arginine, the L-arginine comprising free individual molecules of L-arginine, the free individual molecules of L-arginine L present at a concentration of greater than about 0.1 weight percent, a carrier, and a sugar comprising at least one of a monosaccharide and disaccharide, at least two distinct live lactic acid probiotics, wherein one is a lactic acid producing bacterium, and one is a lactic acid fermenting bacterium, wherein the composition is in configuration suitable to be maintained substantively dissolved within the oral cavity, and wherein the composition is in an effective amount to selectively promote stimulation of a first oral microbiota to produce an excretion product, and wherein a second oral microbiota metabolizes the excretion product to treat the respiratory allergic condition and/or an oral and/or sinus infection.

## Claims

### Claim 1

A formulated oral prebiotic edible composition useful for promoting a desired oral microbiota to treat a respiratory allergic condition and/or an oral and/or sinus infection condition in a subject in need of such treatment, the oral prebiotic comprising:
a free amino acid containing ingredient comprising L-arginine, the L-arginine comprising free individual molecules of L-arginine, the free individual molecules of L-arginine L present at a concentration of greater than about 0.1 weight percent;
a carrier, and a sugar comprising at least one of a monosaccharide and disaccharide;
at least two distinct live lactic acid probiotics, wherein one is a lactic acid producing bacterium, and one is a lactic acid fermenting bacterium;
wherein the composition is in a configuration suitable to be maintained substantially dissolved within the oral cavity for over a period of at least about 1 minute to about an hour, and wherein the composition is in an effective amount to selectively promote stimulation of a first oral microbiota to produce an excretion product, and wherein a second oral microbiota metabolizes the excretion product to treat the respiratory allergic condition and/or an oral and/or sinus infection condition.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the excretion product comprises a short chain fatty acid.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the excretion product includes a sugar moiety.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the composition is in a candy configuration.

### Claim 5 (depends on 4)

The composition of claim 4, wherein the candy configuration includes a lollipop configuration.

### Claim 6 (depends on 4)

The composition of claim 4, wherein the candy configuration includes a chocolate configuration.

### Claim 7 (depends on 4)

The composition of claim 4, wherein the candy configuration includes a soft candy configuration.

### Claim 8 (depends on 4)

The composition of claim 4, wherein the candy configuration includes a creamy candy configuration.

### Claim 9 (depends on 1)

The composition of claim 1, wherein the oral prebiotic further comprises a conventional foodstuff.

### Claim 10 (depends on 9)

The composition of claim 9, wherein the conventional foodstuff includes a cocoa powder.

### Claim 11 (depends on 9)

The composition of claim 9, wherein the conventional foodstuff includes a honey.

### Claim 12 (depends on 9)

The composition of claim 9, wherein the conventional foodstuff includes a cinnamon.

### Claim 13 (depends on 9)

The composition of claim 9, wherein the conventional foodstuff includes a vanilla extract.

### Claim 14 (depends on 9)

The composition of claim 9, wherein the conventional foodstuff includes a corn syrup.

### Claim 15 (depends on 1)

The composition of claim 1, wherein the oral prebiotic further comprises a fatty acid.

### Claim 16 (depends on 1)

The composition of claim 1, wherein the oral prebiotic further comprises a hydrogenated coconut oil.

### Claim 17 (depends on 1)

The composition of claim 1, wherein the oral prebiotic further comprises a mineral supplement.

### Claim 18 (depends on 17)

The composition of claim 17, wherein the mineral supplement includes a calcium lactate gluconate.

### Claim 19 (depends on 1)

The composition of claim 1, wherein the oral prebiotic further comprises a fruit.

### Claim 20 (depends on 19)

The composition of claim 19, wherein the fruit includes a drupe.