# US 11,896,629 B2 · Probiotic therapies for treating Rett syndrome

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- Number: US 11,896,629 B2
- Document ID: US11896629B2
- Status: Granted
- Kind: B2
- Application number: 16/935,837
- Filed: 2020-07-22
- Published: 2021-01-07
- Granted: 2024-02-13
- Earliest claimed: 2010-10-07
- Assignees: California Institute of Technology
- Applicants: California Institute of Technology
- Inventors: Sarkis K Mazmanian; Paul H Patterson; Janet Chow; Elaine Hsiao; Sara W McBride
- Web page: https://patentgrep.com/patent/US11896629B2

## CPC

- A61K 35/741: Probiotics (probiotic yeast, e.g. saccharomyces A61K36/06)
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 25/20: Hypnotics; Sedatives
- A61P 25/22: Anxiolytics
- A61K 2035/11: {Medicinal preparations comprising living procariotic cells}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided is a method and a composition for improving behavioral performance in an individual comprising identifying an individual in need of treatment, and providing such an individual a composition comprising bacteria within the genus Bacteroides.

## Claims

### Claim 1

A method for ameliorating Rett syndrome or a symptom thereof in a subject in need thereof, consisting of administering to the subject a single composition comprising a single Bacteroides bacteria species, wherein the bacterial species is B fragilis, B. thetaiotaomicron, or B. vulgatus.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition is a tablet, a granule, a powder, a capsule, a liquid, or a food composition.

### Claim 3 (depends on 1)

The method of claim 1, wherein the bacteria is B. fragilis.

### Claim 4 (depends on 1)

The method of claim 1, wherein the subject displays leaky gut.

### Claim 5 (depends on 1)

The method of claim 1, wherein the subject shows improved leaky gut after the subject is administered the composition.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition further comprises a pharmaceutically acceptable carrier.

### Claim 7 (depends on 6)

The method of claim 6, wherein the pharmaceutically acceptable carrier is a stabilizer, antioxidant, emulsifier, lubricant, binder, pH adjustor controller, or isotonic agent.

### Claim 8 (depends on 6)

The method of claim 6, wherein the pharmaceutically acceptable carrier comprises one or more of starch, lactose, glucose, sucrose, dextrin, cellulose, paraffin, glyceride, water, alcohol, or gum arabic.

### Claim 9 (depends on 1)

The method of claim 1, further comprising one or more of vitamin C, vitamin E, selenium, or zinc.

### Claim 10 (depends on 1)

The method of claim 1, wherein the single Bacteroides bacteria species is provided in milk, yogurt, curd, cheese, unfermented milk, fermented milk, milk-based fermented product, ice cream, fermented cereal based product, milk-based powder, infant formula, miso, tempeh, a soy beverage, liquid suspension, dried oral supplement, or a wet oral supplement.

### Claim 11 (depends on 1)

The method of claim 1, wherein the composition comprises a juice or soy beverage.