# US 11,896,624 B2 · Compositions for enhancing hyperthermia therapy

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- Number: US 11,896,624 B2
- Document ID: US11896624B2
- Status: Granted
- Kind: B2
- Application number: 17/874,540
- Filed: 2022-07-27
- Published: 2022-11-10
- Granted: 2024-02-13
- Earliest claimed: 2017-06-13
- Applicants: Houn Simon Hsia
- Inventors: Houn Simon Hsia
- Web page: https://patentgrep.com/patent/US11896624B2

## CPC

- A61K 35/60: Fish, e.g. seahorses; Fish eggs
- A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof
- A61K 36/064: Saccharomycetales, e.g. baker's yeast
- A61K 41/0052: {Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy}
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A composition for decreasing proliferation of cancer cells undergoing hyperthermia therapy is described. Such compositions can include a combination of selenium and fish oil. The respective quantities of selenium and fish oil are provided in amounts effective to synergistically increase the sensitivity of the cancer cells to temperatures in excess of 37° C.

## Claims

### Claim 1

A nutritional supplement for decreasing proliferation of a cancer cell being treated with a hyperthermia therapy protocol, comprising:
an effective first amount of fish oil; and
an effective second amount of selenium, wherein selenium is provided as selenium yeast,
wherein the effective first amount of fish oil and the effective second amount of selenium provide a combined synergistic effect in decreasing proliferation of the cancer cell being treated with the hyperthermia therapy protocol that is greater than a summation of effects of the first effective amount of fish oil and the second effective amount of selenium when provided as monotherapies with the hyperthermia therapy protocol, or wherein
the first effective amount of fish oil provides 12.5 μM to 25 μM fish oil to the cancer cell, the second effective amount of selenium provides 0.5 μg/mL selenium to the cancer cell, and the hyperthermia therapy protocol comprises a temperature of 39° C. to 41° C.

### Claim 2 (depends on 1)

The nutritional supplement of claim 1, where in the nutritional supplement comprises at least three components selected from the group consisting of 10,000 to 50,000 mg maltodextrin; 5,000 to 60,000 mg whey protein isolate; 1,000 to 50,000 mg whey protein concentrate; 40 to 15,000 mg fructooligosaccharides/inulin; 1,000 to 9,000 mg granulated honey; 500 to 15,000 mg oat fiber; 500 to 20,000 mg natural French Vanilla flavor; 500 to 50,000 mg soy protein; 500 to 10,000 mg brownulated powdered brown sugar; 500 to 5,000 mg natural vanilla masking flavor; 200 to 10,000 mg lecithin; 50 to 5,000 mg non-fat milk; 50 to 5,000 mg rice protein powder; 50 to 2,000 mg calcium caseinate; 100 to 7,000 mg flax seed oil; 100 to 7,000 mg canola oil; 100 to 7,000 mg borage oil; 10 to 7,000 mg olive oil; 150 to 10,000 mg fish Oil; 100 to 1,000 mg pure lemon oil; 50 to 1,000 mg pure orange oil; 0.5 to 200 mg mixed tocopherols; 200 to 1,500 mg potassium phosphate; 100 to 5,000 mg calcium carbonate; 150 to 2,500 mg choline bitartrate; 100 to 2,000 mg sodium chloride; 100 to 2,000 mg calcium phosphate tribasic; 50 to 3,000 mg ascorbic acid; 50 to 2,000 mg potassium chloride; 50 to 500 mg magnesium oxide; 30 to 4,000 mcg selenium yeast; 30 to 3,000 mcg chromium yeast; 30 to 2,000 mcg molybdenum yeast; 10 to 5,000 mg inositol; 5 to 200 mg zinc sulfate monohydrate; 5 to 2,000 IU dry vitamin E acetate; 5 to 500 mg niacinamide; 3 to 100 mg ferric orthophosphate; 3 to 200 mg calcium pantothenate; 3 to 100 mg manganese sulfate monohydrate; 1 to 100 mg beta carotene; 1 to 15 mg copper gluconate; 25 to 5,000 IU vitamin D3; 2 to 1000 mcg vitamin K2; 0.5 to 200 mg pyridoxine HCl; 0.5 to 1,500 mg potassium iodide; 0.5 to 1,000 mg riboflavin; 0.5 to 2,500 mg thiamine hydrochloride; 1 to 500 mcg dry vitamin K1; 500 to 100,000 IU vitamin A acetate; 100 to 10,000 mcg folic acid; 10 to 10,000 mcg d-biotin; 1 to 3,000 mcg vitamin B12; 300 to 30,000 mg L-carnitine; 500 to 60,000 mg L-glutamine; 500 to 30,000 mg L-arginine base; 50 to 2,000 mg taurine; 50 to 2,000 mg L-lysine; 10 to 1,000 mg alpha lipoic acid; 15 to 1,500 mg resveratrol; 10 to 5,000 mg co-enzyme Q10; 5 to 1,000 mg glycine; 5 to 1,000 mg proline; 2 to 500 mg Lactobacillus acidophilus; 2 to 500 mg Bifidobacterium bifidium; 2 to 500 mg Lactobacillus bulgaricus; 2 to 500 mg Bifidobacterium longum; 2 to 500 mg Streptococcus thermophilus; 5 to 100 mg papain; 5 to 100 mg pepsin; 5 to 100 mg lipase; 5 to 100 mg bromelain; 1 to 100 mg lactase; 3 to 100 mg betaine HCl; 2 to 500 mg pineapple juice powder; 2 to 500 mg papaya fruit powder; 30 to 3,000 mg quercetin; 25 to 600 mg epigallocatechin gallate (EGCG); 15 to 500 mg oligomeric proanthocyanidin (OPC); 15 to 5,000 mg anthocyanins; 10 to 300 mg ellagic acid; 2 to 90 mg astaxanthin; 20 to 1,500 mg fucoidan; 5 to 6,000 mg Cordyceps; 15 to 10,000 mg Ganoderma lucidum; 40 to 15,000 mg Shiitake; 30 to 15,000 mg Maitake; and 30 to 15000 mg Turkey Tail.

### Claim 3 (depends on 1)

The nutritional supplement of claim 1, where in the nutritional supplement comprises at least three components selected from the group consisting of 10,000 to 50,000 mg maltodextrin; 5,000 to 60,000 mg whey protein isolate; 1,000 to 50,000 mg whey protein concentrate; 40 to 15,000 mg fructooligosaccharides/inulin; 1,000 to 9,000 mg granulated honey; 500 to 15,000 mg oat fiber; 500 to 20,000 mg natural French Vanilla flavor; 500 to 50,000 mg soy protein; 500 to 10,000 mg brownulated powdered brown sugar; 500 to 5,000 mg natural vanilla masking flavor; 200 to 10,000 mg lecithin; 50 to 5,000 mg non-fat milk; 50 to 5,000 mg rice protein powder; 50 to 2,000 mg calcium caseinate; 100 to 7,000 mg flax seed oil; 100 to 7,000 mg canola oil; 100 to 7,000 mg borage oil; 10 to 7,000 mg olive oil; 150 to 10,000 mg fish Oil; 100 to 1,000 mg pure lemon oil; 50 to 1,000 mg pure orange oil; 0.5 to 200 mg mixed tocopherols; 200 to 1,500 mg potassium phosphate; 100 to 5,000 mg calcium carbonate; 150 to 2,500 mg choline bitartrate; 100 to 2,000 mg sodium chloride; 100 to 2,000 mg calcium phosphate tribasic; 50 to 3,000 mg ascorbic acid; 50 to 2,000 mg potassium chloride; 50 to 500 mg magnesium oxide; 30 to 4,000 mcg selenium yeast; 30 to 3,000 mcg chromium yeast; 30 to 2,000 mcg molybdenum yeast; 10 to 5,000 mg inositol; 5 to 200 mg zinc sulfate monohydrate; 5 to 2,000 IU dry vitamin E acetate; 5 to 500 mg niacinamide; 3 to 100 mg ferric orthophosphate; 3 to 200 mg calcium pantothenate; 3 to 100 mg manganese sulfate monohydrate; 1 to 100 mg beta carotene; 1 to 15 mg copper gluconate; 25 to 5,000 IU vitamin D3; 2 to 1000 mcg vitamin K2; 0.5 to 200 mg pyridoxine HCl; 0.5 to 1,500 mg potassium iodide; 0.5 to 1,000 mg riboflavin; 0.5 to 2,500 mg thiamine hydrochloride; 1 to 500 mcg dry vitamin K1; 500 to 100,000 IU vitamin A acetate; 100 to 10,000 mcg folic acid; 10 to 10,000 mcg d-biotin; 1 to 3,000 mcg vitamin B12; 300 to 30,000 mg L-carnitine; 500 to 60,000 mg L-glutamine; 500 to 30,000 mg L-arginine base; 50 to 2,000 mg taurine; 50 to 2,000 mg L-lysine; 10 to 1,000 mg alpha lipoic acid; 15 to 1,500 mg resveratrol; 10 to 5,000 mg co-enzyme Q10; 5 to 1,000 mg glycine; 5 to 1,000 mg proline; 2 to 500 mg Lactobacillus acidophilus; 2 to 500 mg Bifidobacterium bifidium; 2 to 500 mg Lactobacillus bulgaricus; 2 to 500 mg Bifidobacterium longum; 2 to 500 mg Streptococcus thermophilus; 5 to 100 mg papain; 5 to 100 mg pepsin; 5 to 100 mg lipase; 5 to 100 mg bromelain; 1 to 100 mg lactase; 3 to 100 mg betaine HCl; 2 to 500 mg pineapple juice powder; 2 to 500 mg papaya fruit powder; 30 to 3,000 mg quercetin; 25 to 600 mg epigallocatechin gallate (EGCG); 15 to 500 mg oligomeric proanthocyanidin (OPC); 15 to 5,000 mg anthocyanins; 10 to 300 mg ellagic acid; 2 to 90 mg astaxanthin; 20 to 1,500 mg fucoidan; 5 to 6,000 mg Cordyceps; 15 to 10,000 mg Ganoderma lucidum; 40 to 15,000 mg Shiitake; 30 to 15,000 mg Maitake; and 30 to 15000 mg Turkey Tail.