Methods for treating and/or preventing graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with hematopoietic stem cell transplant
AssigneesOmeros Corporation, University of Leicester
InventorsGregory A. Demopulos, Thomas Dudler, Hans-Wilhelm Schwaeble
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Abstract
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with a hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.
Claims10
A method of treating a human subject suffering from, or at risk for developing, diffuse alveolar hemorrhage associated with hematopoietic stem cell transplant, the method comprising administering to the subject a composition comprising an amount of a MASP-2 inhibitory antibody, or antigen-binding fragment thereof, effective to inhibit MASP-2-dependent complement activation.
Dependencies are inferred from the claim text.