Resurrection of antibiotics that MRSA resists by silver-doped bioactive glass-ceramic particles
AssigneeBoard of Trustees of Michigan State University
InventorsXanthippi Chatzistavrou, Neal D. Hammer, Aljoscha Roch
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Abstract
A method of treating a bacterial infection including bacteria that have become resistant to an antibiotic in a subject in need thereof is provided. The method includes administering to the subject a safe and therapeutically effective amount of the antibiotic and a reviving agent selected from the group consisting of glass-ceramic particles, silver ions, and combinations thereof. The reviving agent restores antibiotic activity to the antibiotic against the bacteria.
Claims18
A bioactive glass-ceramic scaffold comprising:
- an interconnected web of struts that define a three dimensional porous structure, the struts comprising a glass-ceramic material system synthesized from SiO2, CaO, P2O5, Al2O3, Na2O, K2O, and optionally Ag2O, the glass-ceramic material system including an amorphous phase and at least one crystalline phase, the struts having an average width of greater than or equal to about 50 μm to less than or equal to about 150 μm,
- wherein the bioactive glass-ceramic scaffold has antibiotic activity,
- wherein the bioactive glass-ceramic scaffold promotes proliferation and differentiation of cells that are in contact with the bioactive glass-ceramic scaffold, and
- wherein the bioactive glass-ceramic scaffold has a compressive strength of greater than or equal to about 0.1 MPa to less than or equal to about 2 MPa.
A bioactive glass-ceramic scaffold comprising:
- an interconnected web of struts that define a three dimensional porous structure, the struts comprising a glass-ceramic material system synthesized from SiO2, CaO, P2O5, Al2O3, Na2O, K2O, and optionally Ag2O, the glass-ceramic material system including an amorphous phase and at least one crystalline phase, the struts having an average width of greater than or equal to about 50 μm to less than or equal to about 150 μm, wherein
- the bioactive glass-ceramic scaffold has antibiotic activity,
- the bioactive glass-ceramic scaffold promotes proliferation and differentiation of cells that are in contact with the bioactive glass-ceramic scaffold, and
- the bioactive glass-ceramic scaffold has a compressive strength of greater than or equal to about 0.1 MPa to less than or equal to about 2 MPa, and
- the at least one crystalline phase comprises hydroxyapatite, cristobalite, pseudowollastonite, and wollastonite.
A bioactive glass-ceramic scaffold comprising:
- an interconnected web of struts that define a three dimensional porous structure, the struts comprising a glass-ceramic material system synthesized from SiO2, CaO, P2O5, Al2O3, Na2O, K2O, and Ag2O, the glass-ceramic material system including an amorphous phase and at
- least one crystalline phase, the struts having an average width of greater than or equal to about 50 μm to less than or equal to about 150 μm, wherein
- the bioactive glass-ceramic scaffold has antibiotic activity,
- the bioactive glass-ceramic scaffold promotes proliferation and differentiation of cells that are in contact with the bioactive glass-ceramic scaffold,
- the bioactive glass-ceramic scaffold has a compressive strength of greater than or equal to about 0.1 MPa to less than or equal to about 2 MPa,
- the bioactive glass-ceramic scaffold has as porosity of greater than or equal to about 60% to less than or equal to about 99%, and
- the bioactive glass-ceramic scaffold has an average pore size of greater than or equal to about 400 μm to less than or equal to about 600 μm.
Dependencies are inferred from the claim text.