# US 11,896,594 B2 · Palatable antiparasitic formulations

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- Number: US 11,896,594 B2
- Document ID: US11896594B2
- Status: Granted
- Kind: B2
- Application number: 17/273,111
- Filed: 2019-09-03
- Published: 2021-07-22
- Granted: 2024-02-13
- Earliest claimed: 2018-09-05
- Assignees: Zoetis Services LLC
- Applicants: Zoetis Services LLC
- Inventors: Sachin Pundlik Kolhe; Supriya Gautam Thakur
- Web page: https://patentgrep.com/patent/US11896594B2

## CPC

- A61K 31/506: not condensed and containing further heterocyclic rings
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/2018: {Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates}
- A61K 9/2054: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- A61K 9/2068: {Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/2013)}
- A61K 31/365: Lactones
- A61K 31/4155: non condensed and containing further heterocyclic rings
- A61K 31/422: not condensed and containing further heterocyclic rings
- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61P 33/00: Antiparasitic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention is directed to a palatable, hard chewable composition comprising a therapeutically effective amount of a veterinary acceptable isoxazoline, a stabilized macrocyclic lactone, an acceptable salt form of pyrantel, at least one natural animal based palatant, and at least one veterinary acceptable excipient; and methods for treating or preventing a parasitic infection or infestation in an animal in need thereof with said composition.

## Claims

### Claim 1

A palatable, hard chewable tablet veterinary composition comprising:
a. a therapeutically effective amount of sarolaner;
b. stabilized moxidectin wherein the moxidectin is stabilized with hydroxypropylmethyl cellulose and meglumine;
c. pyrantel pamoate;
d. at least one natural animal meat based palatant;
e. at least one veterinary acceptable excipient; and
f. optionally, at least one additional veterinary antiparasitic agent.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the hydroxypropylmethyl cellulose and meglumine are in the amount of about 2 to about 3 w/w % of the total weight of the tablet.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the moxidectin is further stabilized with an antioxidant.

### Claim 4 (depends on 3)

The composition of claim 3, wherein the sarolaner is in the amount of about 1.3 w/w %; the stabilized moxidectin is in the amount of about 0.03 w/w %, the pyrantel pamoate is in the amount of about 16 w/w %, and the natural animal meat based palatant is admixed with at least one other natural based palatant; and wherein the w/w % amounts are based on the total weight of the tablet.

### Claim 5

A method of treating or preventing a parasitic infection or infestation in an animal in need thereof, by administering a palatable, hard chewable tablet veterinary composition comprising:
a. a therapeutically effective amount of sarolaner;
b. stabilized moxidectin wherein the moxidectin is stabilized with hydroxypropylmethyl cellulose and meglumine;
c. pyrantel pamoate;
d. at least one natural animal meat based palatant;
e. at least one veterinary acceptable excipient; and
f. optionally, at least one additional veterinary antiparasitic agent.

### Claim 6 (depends on 5)

The method of claim 5 wherein the hydroxypropylmethyl cellulose and meglumine are in the amount of about 2 w/w % to about 3 w/w % of the total weight of the tablet.

### Claim 7 (depends on 6)

The method of claim 6 wherein the animal is a companion animal.

### Claim 8 (depends on 7)

The method of claim 7 wherein the companion animal is canine.

### Claim 9

A palatable, hard chewable tablet veterinary composition comprising:
a. a therapeutically effective amount of sarolaner;
b. stabilized moxidectin and wherein the moxidectin is stabilized with hydroxypropylmethyl cellulose and meglumine;
c. pyrantel pamoate;
d. at least one natural animal meat based palatant;
e. at least one veterinary acceptable excipient; and
f. optionally, at least one additional veterinary antiparasitic agent, for the treatment or prevention of a parasitic infection or infestation in an animal.

### Claim 10 (depends on 9)

The composition of claim 9 wherein the hydroxypropylmethyl cellulose and meglumine are in the amount of about 2 to about 3 w/w % of the total weight of the tablet.

### Claim 11 (depends on 10)

The composition of claim 10, wherein the sarolaner is in the amount of about 1.3 w/w %; the stabilized moxidectin is in the amount of about the pyrantel pamoate is in the amount of about 16 w/w %, and the natural animal meat based palatant is admixed with at least one other natural based palatant; and wherein the w/w % amounts are based on the total weight of the tablet.

### Claim 12 (depends on 11)

The composition of claim 11, wherein the palatant admixture comprises about 40 to 45% of the total weight of the tablet.