# US 11,896,584 B2 · Oxazolidinone for treatment of infections with Mycobacterium tuberculosis

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- Number: US 11,896,584 B2
- Document ID: US11896584B2
- Status: Granted
- Kind: B2
- Application number: 18/060,823
- Filed: 2022-12-01
- Published: 2023-03-30
- Granted: 2024-02-13
- Earliest claimed: 2016-02-17
- Assignees: The Johns Hopkins Universty; University of St. Thomas
- Applicants: The Johns Hopkins University; University of St. Thomas
- Inventors: Gyanu Lamichhane; J. Thomas Ippoliti
- Web page: https://patentgrep.com/patent/US11896584B2

## CPC

- A61K 31/4245: Oxadiazoles
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 31/422: not condensed and containing further heterocyclic rings
- A61P 31/06: for tuberculosis
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention is a method of treating or preventing Mycobacterium tuberculosis infection in a subject by administering to the subject an effective amount of oxazolidinone, specifically (N—(((S)-3-(dibenzo[b,e][1,4]dioxin-7-yl)-2-oxooxazolidin-5-yl)methyl)acetamide) or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.

## Claims

### Claim 1

A method for treating or preventing a methicillin-sensitive and/or methicillin-resistant Staphylococcus aureus infection in a subject in need thereof, the method comprising administering to the subject an effective amount of (N—(((S)-3-(dibezo[b,e][1,4]dioxin-7-yl)-2-oxooxazolidin-5-yl)methyl)acetamide) or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.

### Claim 2 (depends on 1)

The method of claim 1 wherein the subject is a human.

### Claim 3 (depends on 1)

The method of claim 1 wherein the subject is an animal.

### Claim 4 (depends on 1)

The method of claim 1 further administering at least one or more antimicrobial compounds.