# US 11,896,581 B2 · Compositions and methods for providing health benefits in an animal > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,896,581 B2 - Document ID: US11896581B2 - Status: Granted - Kind: B2 - Application number: 17/398,499 - Filed: 2021-08-10 - Published: 2022-03-10 - Granted: 2024-02-13 - Earliest claimed: 2020-09-04 - Assignees: Societe des Produits Nestle S.A. - Applicants: Société des Produits Nestlé S.A. - Inventors: Francois-Pierre Martin; Christian Darimont-Nicolau; Andreas Rytz - Web page: https://patentgrep.com/patent/US11896581B2 ## CPC - A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine - A23K 20/121: containing oxygen or sulfur as hetero atom - A23K 20/142: Amino acids; Derivatives thereof - A23K 50/40: for carnivorous animals, e.g. cats or dogs - A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)} - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23K: FODDER ## Abstract The present disclosure provides compositions and methods for providing a health benefit to an animal utilizing ferulic acid and histidine. For example, a composition can contain ferulic acid and histidine in therapeutically effective amounts for providing the health benefit to the animal. ## Claims ### Claim 1 A composition for providing at least one health benefit to an animal, the composition comprising ferulic acid and histidine, wherein the composition contains the ferulic acid and the histidine in therapeutically effective amounts for providing the at least one health benefit to the animal, wherein the ferulic acid is present in the composition in an amount from about 2 mg to about 2 g, and the histidine is present in the composition in an amount from about 0.5 g to about 21 g, wherein the at least one health benefit is selected from the group consisting of prevention of diabetes, treatment of diabetes, delayed onset of diabetes, prevention of pre-diabetes, delayed onset of pre-diabetes, treatment of pre-diabetes, prevention of insulin resistance, treatment of insulin resistance, and delayed onset of insulin resistance. ### Claim 2 (depends on 1) The composition of claim 1, wherein the ferulic acid is present in the composition in an amount from about 5 mg to about 1 g, and the histidine is present in the composition in an amount from about 1 g to about 10 g. ### Claim 3 (depends on 1) The composition of claim 1, wherein the ferulic acid is present in the composition in an amount from about 10 mg to about 500 mg. ### Claim 4 (depends on 1) The composition of claim 1, wherein the histidine is present in the composition in an amount from about 1 g to about 5 g. ### Claim 5 (depends on 1) The composition of claim 1, wherein the composition is a main meal composition. ### Claim 6 (depends on 1) The composition of claim 1, wherein the composition is a supplement. ### Claim 7 (depends on 1) The composition of claim 1, wherein the composition is formulated for a companion animal. ### Claim 8 (depends on 1) The composition of claim 1, wherein the composition is formulated for a feline. ### Claim 9 (depends on 1) The composition of claim 1, wherein the composition further comprises protein, fat, carbohydrates, and fiber. ### Claim 10 (depends on 1) The composition of claim 1, wherein the composition further comprises an additive effective for glucose control or diabetic management. ### Claim 11 A method for providing at least one health benefit to an animal, the method comprising administering a composition to the animal, wherein the composition comprises ferulic acid and histidine in therapeutically effective amounts to provide the at least one health benefit to the animal, wherein the ferulic acid is present in the composition in an amount from about 2 mg to about 2 g, and the histidine is present in the composition in an amount from about 0.5 g to about 21 g, wherein the at least one health benefit is selected from the group consisting of prevention of diabetes, treatment of diabetes, delayed onset of diabetes, prevention of pre-diabetes, delayed onset of pre-diabetes, treatment of pre-diabetes, prevention of insulin resistance, treatment of insulin resistance, and delayed onset of insulin resistance. ### Claim 12 (depends on 11) The method of claim 11, wherein the composition is administered to the animal on a regular basis. ### Claim 13 (depends on 11) The method of claim 11, wherein the administration provides a histidine dosage of about 1 mg/kgBW/day to about 2 g/kgBW/day and a ferulic acid dosage of about 0.5 mg/kgBW/day to about 500 mg/kgBW/day. ### Claim 14 (depends on 11) The method of claim 11, wherein the ferulic acid is present in the composition in an amount from about 5 mg to about 1 g, and the histidine is present in the composition in an amount from about 1 g to about 10 g. ### Claim 15 (depends on 11) The method of claim 11, wherein the ferulic acid is present in the composition in an amount from about 10 mg to about 500 mg and the histidine is present in the composition in an amount from about 1 g to about 5 g. ### Claim 16 (depends on 11) The method of claim 11, wherein the composition is a main meal composition. ### Claim 17 (depends on 11) The method of claim 11, wherein the composition is a supplement. ### Claim 18 (depends on 11) The method of claim 11, wherein the composition is a formulated for a companion animal. ### Claim 19 (depends on 11) The method of claim 11, wherein the composition is formulated for a feline. ### Claim 20 (depends on 11) The method of claim 11, wherein the composition further comprises an additive effective for glucose control or diabetic management.