# US 11,896,580 B2 · Composition for improving milk quality and preparation method and application thereof

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- Number: US 11,896,580 B2
- Document ID: US11896580B2
- Status: Granted
- Kind: B2
- Application number: 17/502,735
- Filed: 2021-10-15
- Published: 2022-04-21
- Granted: 2024-02-13
- Earliest claimed: 2020-10-16
- Assignees: China Agricultural University
- Applicants: China Agricultural University
- Inventors: Guoshi Liu; Hao Wu; Yongqiang Lu; Lu Zhang; Hui Ma; Yi Chang; Qiaoxiang Liu; Songyang Yao; Pengyun Ji
- Web page: https://patentgrep.com/patent/US11896580B2

## CPC

- A61K 31/4045: Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A61P 15/14: for lactation disorders, e.g. galactorrhoea
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The disclosure discloses a composition containing melatonin as an effective ingredient, and its application in improving DHI production performance and improving milk quality. The composition containing melatonin as an effective ingredient according to the present disclosure can significantly reduce the somatic cell count in milk and improve milk quality. Under the conditions of different seasons, ages, and lactation periods, the administration of the composition containing melatonin as an active ingredient according to the present disclosure can significantly reduce the somatic cell score of cow milk (p<0.01), increase the protein content and lactose content in milk, and meanwhile reduce the fat content and urea nitrogen content in milk. In summary, the composition containing melatonin as an effective ingredient according to the present disclosure can improve the quality of milk and increase the efficiency of dairy cow breeding.

## Claims

### Claim 1

A composition for improving milk quality of a dairy cow, comprising melatonin as an active ingredient, absolute ethanol and physiological saline; wherein the concentration of melatonin in the composition is of 1 to 20 mg/mL, and the volume ratio of absolute ethanol to physiological saline is in a range of (1-3):(1-2).

### Claim 2 (depends on 1)

The composition according to claim 1, wherein the volume ratio of absolute ethanol to physiological saline is 3:2.

### Claim 3 (depends on 1)

A method for preparing the composition of claim 1, comprising the following steps: dissolving melatonin in absolute ethanol and then adding physiological saline, wherein the steps are carried out in dark, the concentration of melatonin in the composition is of 1 to 20 mg/ml, and the volume ratio of absolute ethanol to physiological saline is in a range of (1-3):(1-2).

### Claim 4 (depends on 3)

The method according to claim 3, wherein the volume ratio of absolute ethanol to physiological saline is 3:2.