# US 11,896,568 B2 · Compositions and methods for treating patients suffering from glioma or leukemia

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- Number: US 11,896,568 B2
- Document ID: US11896568B2
- Status: Granted
- Kind: B2
- Application number: 17/501,692
- Filed: 2021-10-14
- Published: 2022-03-03
- Granted: 2024-02-13
- Earliest claimed: 2016-11-02
- Assignees: University of Cincinnati
- Applicants: University of Cincinnati
- Inventors: Jianjun Chen; Rui Su
- Web page: https://patentgrep.com/patent/US11896568B2

## CPC

- A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A61K 31/225: Polycarboxylic acids
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 31/706: containing six-membered rings with nitrogen as a ring hetero atom
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61K 31/203: Retinoic acids {; Salts thereof}
- A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)}
- A61K 31/7068: having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Pharmaceutical compositions, kits and methods for treating tumors such as glioma and cancers such as leukemia with (R)-2-hydroxyglutarate (R-2HG) are provided, along with therapeutic regimens including treatment of a patient suffering from glioma or leukemia with a MYC-signaling inhibitor followed by or cotemporaneous with treatment with R-2HG, and optionally other chemotherapeutic agents.

## Claims

### Claim 1

A method of treating leukemia in a subject in need thereof, the method comprising administering to the subject a combination of:
an effective amount of R-2HG; and
one or more chemotherapeutic agents selected from the group consisting of all trans retinoic acid (ATRA), azacitidine (AZA), daunorubicin, and decitabine.

### Claim 2 (depends on 1)

The method according to claim 1, further comprising administering at least one agent effective for inhibiting MYC signaling prior to administering the R-2HG.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the at least one agent effective for inhibiting MYC signaling is selected from the group consisting of flavopiridol, purvalanol A, SU9516, PHA 767491 HCl, SNS-032, JQ1, SGI-1776, EPZ004777, C464, SAHA, triptolide, nutlin-3a, SB220025, LY294002, VAV-939, LY-411575, VX-680, NSC71948, ABT263, VER-155008, KW-2478, SB 218078, and leflunomide.

### Claim 4 (depends on 2)

The method according to claim 2, wherein the subject is characterized by possessing a mutant form of IDH1 and/or an IDH2.