# US 11,896,374 B2 · Analyte sensor > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,896,374 B2 - Document ID: US11896374B2 - Status: Granted - Kind: B2 - Application number: 16/776,229 - Filed: 2020-01-29 - Published: 2020-05-28 - Granted: 2024-02-13 - Earliest claimed: 2008-03-25 - Assignees: DexCom, Inc. - Applicants: DexCom, Inc. - Inventors: Apurv Ullas Kamath; Peter C. Simpson; Mark Brister - Web page: https://patentgrep.com/patent/US11896374B2 ## CPC - A61B 5/1455: using optical sensors, e.g. spectral photometrical oximeters - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/14542: {for measuring blood gases (A61B5/14551 takes precedence)} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 5/14551: {for measuring blood gases} - A61B 5/1459: invasive, e.g. introduced into the body by a catheter - A61B 5/14865: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors} - A61B 5/1495: Calibrating or testing of in-vivo probes - A61B 5/7203: {for noise prevention, reduction or removal} - A61B 5/4094: {Diagnosing or monitoring seizure diseases, e.g. epilepsy} - A61B 5/6852: {Catheters} - A61B 2560/0223: of calibration, e.g. protocols for calibrating sensors - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. ## Claims ### Claim 1 A system for detecting glucose, comprising: a first sensor configured to be implanted in a host, wherein the first sensor is configured to generate a first signal and a second signal, wherein the first signal is associated with glucose and wherein the second signal is associated with a reference analyte that is non-glucose; a second sensor configured to generate a reference signal associated with the reference analyte; and at least one processor configured to: determine a sensitivity associated with the first sensor using the reference signal from the second sensor and the second signal from the first sensor, and determine a glucose concentration using the sensitivity associated with the first sensor and the first signal from the first sensor. ### Claim 2 (depends on 1) The system of claim 1, wherein the first sensor comprises an electrochemical sensor. ### Claim 3 (depends on 1) The system of claim 1, wherein the first sensor is configured to measure the glucose in interstitial fluid. ### Claim 4 (depends on 1) The system of claim 1, wherein the second sensor comprises an optical sensor. ### Claim 5 (depends on 1) The system of claim 1, wherein the reference analyte is oxygen. ### Claim 6 A method for detecting glucose, comprising: providing a first sensor configured to be implanted in a host, wherein the first sensor is configured to generate a first signal and a second signal, wherein the first signal is associated with glucose and wherein the second signal is associated with a reference analyte that is non-glucose; providing a second sensor configured to generate a reference signal associated with the reference analyte; and providing at least one processor, the at least one processor configured to: determine a sensitivity associated with the first sensor using the reference signal from the second sensor and the second signal from the first sensor, and determine a glucose concentration using the sensitivity of the first sensor and the first signal from the first sensor. ### Claim 7 (depends on 6) The method of claim 6, wherein the at least one processor is a single processor. ### Claim 8 (depends on 6) The method of claim 6, wherein the first sensor comprises an electrochemical sensor. ### Claim 9 (depends on 6) The method of claim 6, wherein the first sensor is configured to measure the glucose in interstitial fluid. ### Claim 10 (depends on 6) The method of claim 6, wherein the second sensor comprises an optical sensor. ### Claim 11 (depends on 6) The method of claim 6, wherein the reference analyte is oxygen. ### Claim 12 A system for detecting glucose, comprising: a first sensor configured to be implanted in a host, wherein the first sensor is configured to generate a signal associated with glucose; a second sensor configured to be implanted in a host, wherein the second sensor is configured to generate a signal associated with a reference analyte that is non-glucose; a reference sensor configured to generate a reference signal associated with the reference analyte; and at least one processor configured to: determine a sensitivity associated with the first sensor using the reference signal from the reference sensor and the signal associated with the reference analyte from the second sensor, and determine a glucose concentration using the sensitivity associated with the first sensor and the signal associated with glucose from the first sensor. ### Claim 13 (depends on 12) The system of claim 12, wherein the first sensor comprises an electrochemical sensor. ### Claim 14 (depends on 12) The system of claim 12, wherein the second sensor comprises an optical sensor. ### Claim 15 (depends on 12) The system of claim 12, wherein the reference analyte is oxygen. ### Claim 16 A method for detecting glucose, comprising: providing a first sensor configured to be implanted in a host, wherein the first sensor is configured to generate a signal is associated with glucose; providing a second sensor configured to be implanted in the host, wherein the second sensor is configured to generate a signal associated with a reference analyte that is non-glucose; providing a reference sensor configured to generate a reference signal associated with the reference analyte; and providing at least one processor, the at least one processor configured to: determine a sensitivity associated with the first sensor using the reference signal from the reference sensor and the signal associated with the reference analyte from the second sensor, and determine a glucose concentration using the sensitivity of the first sensor and the signal associated with glucose from the first sensor. ### Claim 17 (depends on 16) The method of claim 16, wherein the at least one processor is a single processor. ### Claim 18 (depends on 16) The method of claim 16, wherein the first sensor comprises an electrochemical sensor. ### Claim 19 (depends on 16) The method of claim 16, wherein the second sensor comprises an optical sensor. ### Claim 20 (depends on 16) The method of claim 16, wherein the reference analyte is oxygen.