# US 11,896,304 B2 · In vivo pre-surgical characterization of cataractous lenses

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- Number: US 11,896,304 B2
- Document ID: US11896304B2
- Status: Granted
- Kind: B2
- Application number: 18/179,203
- Filed: 2023-03-06
- Published: 2023-08-17
- Granted: 2024-02-13
- Earliest claimed: 2017-05-02
- Assignees: Alcon Inc.
- Applicants: Alcon Inc.
- Inventors: Zsolt Bor; Mikhail Ovchinnikov
- Web page: https://patentgrep.com/patent/US11896304B2

## CPC

- A61B 3/0025: {characterised by electronic signal processing, e.g. eye models}
- A61B 5/0059: {using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455)}
- A61B 8/00: Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B 8/10: Eye inspection
- A61F 2/16: Intraocular lenses
- A61F 9/0017: {implantable in, or in contact with, the eye, e.g. ocular inserts}
- A61F 9/008: using laser
- A61F 2009/00855: {Calibration of the laser system}
- A61F 2009/0087: {Lens}
- A61F 2009/00887: {Cataract}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

Systems and methods are provided for in vivo pre-surgical characterization of lenses, such as cataractous lenses. A method comprises obtaining an electromagnetically-measured value related to the axial thickness of the lens, obtaining an ultrasound-measured value related to the axial thickness of the lens, calculating a relationship value based upon the electromagnetically-measured value and the ultrasound-measured value, and determining a mechanical property value based upon the calculated relationship value. The mechanical property may relate to lens hardness, rigidity, or density, or the amount of energy for a phacoemulsification procedure. A system may comprise an optical interferometer for measuring data to obtain the electromagnetically-measured value and an ultrasound biometer for measuring data to obtain the ultrasound-measured value.

## Claims

### Claim 1

A system for obtaining a pre-surgical characterization of a lens of an eye, the system comprising:
an optical interferometer adapted to transmit electromagnetic energy into the lens of the eye and to capture reflected signals of that electromagnetic energy for obtaining an electromagnetically-measured value related to the axial thickness of the lens;
an ultrasound biometer adapted to transmit an ultrasound signal into the lens of the eye and to capture reflected signals of that ultrasound signal for obtaining an ultrasound-measured value related to the axial thickness of the lens; and
a calculation module comprising one or more processors and computer code stored in memory of the system and executable by the one or more processors of the system, the calculation module configured to:
calculate, when executed by the one or more processors, a relationship value based upon the electromagnetically-measured value related to the axial thickness of the lens and the ultrasound-measured value related to the axial thickness of the lens;
determine, when executed by the one or more processors, an amount of phacoemulsification energy needed in a phacoemulsification procedure based upon the calculated relationship value; and
generate an output for a physician related to the amount of phacoemulsification energy needed in a phacoemulsification procedure.

### Claim 2 (depends on 1)

A system as recited in claim 1, wherein the electromagnetically-measured value is an electromagnetically-measured value for the axial thickness of the lens.

### Claim 3 (depends on 1)

A system as recited in claim 1, wherein the ultrasound-measured value is an ultrasound-measured estimated value for the axial thickness of the lens based upon an assumed velocity of the ultrasound signal.

### Claim 4 (depends on 1)

A system as recited in claim 1, wherein the electromagnetically-measured value is an electromagnetically-measured value for the axial thickness of the lens, the ultrasound-measured value is an ultrasound-measured estimated value for the axial thickness of the lens based upon an assumed velocity of the ultrasound signal, and the relationship value is a ratio of the electromagnetically-measured value and the ultrasound-measured value.

### Claim 5 (depends on 1)

A system as recited in claim 1, wherein the electromagnetic energy transmitted by the optical interferometer is laser light.

### Claim 6 (depends on 1)

A system as recited in claim 1, wherein the ultrasound biometer is an A-scan ultrasound biometer.

### Claim 7 (depends on 1)

A system as recited in claim 1, wherein the optical interferometer is adapted to operate non-invasively to transmit the electromagnetic energy into the lens of the eye and to capture reflected signals of that electromagnetic energy.

### Claim 8 (depends on 1)

A system as recited in claim 1, wherein the ultrasound biometer is adapted to operate non-invasively to transmit the ultrasound signal into the lens of the eye and to capture reflected signals of that ultrasound signal.

### Claim 9 (depends on 1)

A system as recited in claim 1, wherein the system is adapted to operate non-invasively to measure the electromagnetically-measured value in vivo and the ultrasound-measured value in vivo.