# US 11,896,288 B2 · Method and apparatus for magnetic resonance imaging thermometry > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,896,288 B2 - Document ID: US11896288B2 - Status: Granted - Kind: B2 - Application number: 17/879,823 - Filed: 2022-08-03 - Published: 2022-12-01 - Granted: 2024-02-13 - Earliest claimed: 2019-02-21 - Assignees: Medtronic Navigation, Inc. - Applicants: Medtronic Navigation, Inc. - Inventors: Christine R. Drown; Andrew Wald; Rebecca L. Vincelette; William A. Grissom - Web page: https://patentgrep.com/patent/US11896288B2 ## CPC - A61B 18/14: Probes or electrodes therefor - G06T 5/77: Retouching; Inpainting; Scratch removal - A61B 5/01: Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20) - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61B 18/20: using laser - A61B 90/37: {Surgical systems with images on a monitor during operation} - G01R 33/4808: {Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]} - G06T 5/94: based on local image properties, e.g. for local contrast enhancement - G06T 7/74: {involving reference images or patches} - A61B 18/02: by cooling, e.g. cryogenic techniques - A61B 2018/00446: {Brain} - A61B 2018/00577: {Ablation} - A61B 2018/00791: {Temperature} - A61B 2090/374: {NMR or MRI} - A61B 2090/376: {using X-rays, e.g. fluoroscopy} - G01R 33/4804: {Spatially selective measurement of temperature or pH} - G06T 2207/10088: Magnetic resonance imaging [MRI] - G06T 2207/20104: Interactive definition of region of interest [ROI] - G06T 2207/30016: Brain - G06T 2207/30096: Tumor; Lesion - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) ## Abstract A system and method to analyze image data. The image data may be used to assist in determine the presence of a feature in the image. The feature may include a bubble. ## Claims ### Claim 1 A method of selecting a region for determining a presence of a bubble in an image, comprising: tracking a location of at least a portion of an instrument positioned within a subject in a subject space defined by the subject; accessing a current image of the subject having an image space that is registered to the subject space; determining a location of the instrument within the image space based on the tracked location of the instrument and the accessed current image; determining a region of interest in the accessed current image and image space based at least on the determined location of the instrument within the image space; analyzing image data of the current image with at least a bubble image library to determine if a bubble is present in the current image within the region of interest; identifying image portions of the analyzed current image that include the bubble; generating a comparison image by removing the identified image portions in the current image that include the bubble; and outputting feedback to a user in light of the comparison image regarding continuing with a procedure performed by the instrument. ### Claim 2 (depends on 1) The method of claim 1, further comprising: tracking the instrument within the subject space with a tracking system, the location of the instrument is a tracked location; and registering an image space of the current image to the subject space of the subject; wherein the location of the instrument within the image space is determined based on the tracked location of the instrument. ### Claim 3 (depends on 2) The method of claim 2, further comprising: operating the tracking system to determine the tracked location separate from the imaging system. ### Claim 4 (depends on 1) The method of claim 1, wherein analyzing the image data of the current image to determine if the bubble is present in the current image within the region of interest, comprises: comparing at least one bubble image to the current image; determining a correlation between the at least one bubble image and the current image; and outputting a correlation value based on the determined correlation. ### Claim 5 (depends on 4) The method of claim 4, further comprising: accessing the bubble image library including a plurality of bubble images. ### Claim 6 (depends on 4) The method of claim 4, wherein analyzing the image data of the current image to determine if the bubble is present in the current image within the region of interest, further comprises: selecting a first region within the region of interest; performing a pairwise comparison of voxels from the at least one bubble image to the selected first region; selecting a second region within the region of interest; and performing a pairwise comparison of voxels from the at least one bubble image to the selected second region. ### Claim 7 (depends on 1) The method of claim 1, wherein tracking the location of at least the portion of the instrument positioned within the subject in the subject space defined by the subject, comprises: associating a tracking device with the instrument; and operating a tracking system to track the tracking device associated with the instrument. ### Claim 8 (depends on 1) The method of claim 1, wherein determining the region of interest relative to the determined location of the instrument within the image space, comprises: determining a dimension of the region of interest; and centering the region of interest on the location of the instrument. ### Claim 9 (depends on 8) The method of claim 8, wherein the location of the instrument includes the location of only a portion of the instrument. ### Claim 10 A system to select a region for determining a presence of a bubble in an image, comprising: a navigation system operable to: determine a location of an instrument positioned within a subject in a subject space defined by the subject, access a current image of the subject having an image space that is registered to the subject space, and determine a location of the instrument within an image space; and an image analysis processor system operable to execute instructions to: identify a region of interest relative to the determined location of the instrument within the image space, analyze image data of the current image with at least a bubble image library to determine if a bubble is present in the current image within the region of interest, identify image portions of the analyzed current image that include the bubble, generating a comparison image by removing the identified image portions in the current image that include including the bubble, and output feedback to a user in light of the comparison image regarding continuing with a procedure performed by the instrument. ### Claim 11 (depends on 10) The system of claim 10, further comprising: a display device to display a heat map image of the subject based on the current image. ### Claim 12 (depends on 11) The system of claim 11, further comprising: a memory system having stored thereon the bubble image library including a plurality of bubble images; wherein the image analysis processor system is operable to recall the bubble image library. ### Claim 13 (depends on 12) The system of claim 12, wherein the image analysis processor system is operable to execute further instructions to analyze the current image to determine if the bubble is present in the current image within the region of interest by: comparing at least one bubble image recalled from the bubble image library to the current image; determining a correlation between the at least one bubble image and the current image; and outputting a correlation value based on the determined correlation. ### Claim 14 (depends on 10) The system of claim 10, wherein the image analysis processor system is operable to execute further instructions to identify the region of interest by determining a region centered on the determined location of the instrument within the image space. ### Claim 15 A method of selecting a region for determining a presence of a bubble in an image, comprising: accessing a first image and a second image of a subject in which an instrument is positioned; generating a first comparison image by comparing the first image and the second image; determining a location of the instrument within an image space of at least the comparison image based on a determined location of the instrument; determining a region of interest relative to the determined location of the instrument within the image space; correcting at least the second image for determining a temperature of at least the region of interest in the second image; identifying image portions of the comparison image including the bubble; generating a second comparison image by removing the identified image portions of the first comparison image including the bubble; and outputting feedback to a user in light of the second comparison image regarding continuing with a procedure performed by the instrument. ### Claim 16 (depends on 15) The method of claim 15, further comprising: tracking the instrument in a subject space defined by the subject; and registering an image space of the second comparison image to the subject space of the subject. ### Claim 17 (depends on 16) The method of claim 16, further comprising: comparing a plurality of bubble images to the first comparison image; determining a correlation between at least one bubble image of the plurality of bubble images and the first comparison image; and outputting a correlation value based on the determined correlation of the at least one bubble image.