# US 11,896,226 B2 · Compressible adjuncts with healing-dependent degradation profile

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- Number: US 11,896,226 B2
- Document ID: US11896226B2
- Status: Granted
- Kind: B2
- Application number: 17/217,680
- Filed: 2021-03-30
- Published: 2022-10-06
- Granted: 2024-02-13
- Earliest claimed: 2021-03-30
- Assignees: Cilag GmbH International
- Applicants: Cilag GmbH International
- Inventors: Frederick E. Shelton, IV; Michael J. Vendely
- Web page: https://patentgrep.com/patent/US11896226B2

## CPC

- A61B 17/07292: {Reinforcements for staple line, e.g. pledgets}
- A61K 9/0024: {Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L)}
- A61B 2017/00004: {(bio)absorbable, (bio)resorbable or resorptive}
- A61B 2017/00884: {enhancing wound closure}
- A61B 2017/00893: {pharmaceutically effective}
- A61B 2017/00898: {expandable upon contact with fluid}
- A61B 2017/00938: {hydrophobic}
- A61B 2017/00942: {hydrophilic}
- A61B 2017/00964: {composite}
- A61B 2017/07257: {characterised by its anvil}
- A61B 2017/07271: {characterised by its cartridge}
- A61B 2017/07285: {characterised by its cutter}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A compressible adjunct for use with a staple cartridge is provided and includes a biocompatible adjunct material configured to be releasably retained on a staple cartridge and configured to be delivered to tissue by deployment of staples in the staple cartridge. The adjunct material is formed from a porous polymer body and is configured to exhibit a first stiffness in compression that is approximately constant during a first time period from contact with the tissue. The adjunct material is further configured to exhibit a second stiffness in compression during a second time period following the first time period. The second stiffness is less than the first stiffness and is configured to decrease with time as a function of at least one of oxidation, enzyme-catalyzed hydrolysis, and change of pH resulting from interaction with at least one physiological element released from the tissue during healing progression of the tissue.

## Claims

### Claim 1

A compressible adjunct for use with a staple cartridge, the compressible adjunct comprising:
a biocompatible adjunct material configured to be releasably retained on a staple cartridge body and configured to be delivered to tissue by deployment of staples in the staple cartridge body, the adjunct material comprising a porous polymer body configured to exhibit a first stiffness in compression that is approximately constant during a first time period from contact with the tissue and to exhibit a second stiffness in compression during a second time period following the first time period, wherein the second stiffness is less than the first stiffness and is configured to decrease with time as a function of at least one of oxidation, enzyme-catalyzed hydrolysis, and change of pH resulting from interaction with at least one physiological element released from the tissue during healing progression of the tissue.

### Claim 2 (depends on 1)

The adjunct of claim 1, wherein the adjunct material is configured to adopt the second stiffness in response to oxidation resulting from reaction with the at least one physiological element comprising a reactive oxygen species.

### Claim 3 (depends on 2)

The adjunct of claim 2, wherein the reactive oxygen species is at least one of an oxygen containing enzyme, a free radical, a superoxide, and a peroxide.

### Claim 4 (depends on 2)

The adjunct of claim 2, wherein the reactive oxygen species is at least one of O2−, H2O2, NO, and HOCl.

### Claim 5 (depends on 1)

The adjunct of claim 1, wherein the adjunct material is configured to oxidize in response to reaction with the at least one physiological element comprising a reactive oxygen species released by at least one of a mature blood cell, a fybrocyte, and an inflammatory cell.

### Claim 6 (depends on 5)

The adjunct of claim 5, wherein the inflammatory cell is at least one of a leukocyte and a macrophage.

### Claim 7 (depends on 1)

The adjunct of claim 1, wherein the adjunct material is configured adopt the second stiffness in response to hydrolysis catalyzed by an enzyme.

### Claim 8 (depends on 7)

The adjunct of claim 7, wherein the enzyme comprises a lysozyme.

### Claim 9 (depends on 1)

The adjunct of claim 1, wherein adjunct material is configured to adopt the second stiffness in response to a decrease in pH resulting from the presence of the at least one physiological element.