Production and delivery tracking and sample verification of patient-specific therapeutics

A computer assisted method of tracking a biological sample from sample acquisition from a patient to administration to the patient of therapy based on said sample, searching a distributed digital ledger derived therefrom, and thereby validating therapy administration at the point of care, the method comprising:

• obtaining the biological sample from a patient;
• labeling the biological sample with one or more first additives by inserting the one or more first additives into a container comprising the biological sample, wherein the one or more first additives uniquely label the biological sample among a population of biological samples, and wherein the one or more first additives include at least one of a primer, a monoclonal antibody, a rare earth metal, an isotope, or an autologous mitochondria;
• obtaining, via at least one processor, first identifying digital data for the biological sample, wherein the identifying digital data is subjected to a sample tracking protocol to produce a sample tracking chain data structure stored in at least one computer memory, wherein the sample tracking chain data structure is indexed and thereby searchable for the first identifying digital data and the one or more first additives;
• generating a current state block of the distributed digital ledger by executing a secure hash function on at least the one or more first additives and intrinsic biological data of the biological sample;
• providing the labeled biological sample to a manufacturing facility for generation of a labeled patient-specific therapeutic, wherein the labeled therapeutic is subjected to the sample tracking protocol and thereby added, via the at least one processor, to the sample tracking chain data structure;
• receiving the labeled therapeutic from the manufacturing facility, wherein the labeled therapeutic is associated with second identifying digital data;
• validating, via the at least one processor, the labeled therapeutic by detecting the presence of one or more second additives uniquely labeling the therapeutic among a population of therapeutics, wherein the validation is subjected to the sample tracking protocol and thereby added, via the at least one processor, to the sample tracking chain data structure, and the validation includes validating a timestamp of a state block of the distributed digital ledger associated with the second identifying digital data, based on an external public ledger, to confirm the state block associated with the second identifying digital data has not been modified or tampered with;
• and
• thereby validating, via the at least one processor, the labeled therapeutic for administration to the patient, wherein the administration is subjected to the sample tracking protocol and thereby added, via the at least one processor, to the sample tracking chain data structure, wherein the sample tracking chain data structure is indexed and thereby searchable for the second identifying digital data and the one or more second additives.