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US 11,892,945 B2Granted
High-capacity storage of digital information in DNA
AssigneeEuropean Molecular Biology Laboratory
InventorsNick Goldman, John Birney
Life of this patent
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Abstract
A method for storage of an item of information (210) is disclosed. The method comprises encoding bytes (720) in the item of information (210), and representing using a schema the encoded bytes by a DNA nucleotide to produce a DNA sequence (230). The DNA sequence (230) is broken into a plurality of overlapping DNA segments (240) and indexing information (250) added to the plurality of DNA segments. Finally, the plurality of DNA segments (240) is synthesized (790) and stored (795).
Claims20
A method of storing digital information in a plurality of DNA segments, the method comprising:
- a. converting digital information into a plurality of DNA segments, wherein the digital information is in the form of bit sequences or byte sequences stored in a computer file, wherein the digital information comprises text, images, videos, or music, wherein the digital information comprises at least 15646 bytes of information, and wherein at least two of the plurality of DNA segments comprise:
- (i) a region that is overlapping with another DNA segment of the plurality of DNA segments;
- and
- (ii) an indexing information;
- b. generating a library of oligonucleotides comprising the plurality of DNA segments, wherein the library collectively encodes for the digital information;
- c. incorporating adapters to ends of the plurality of DNA segments to facilitate sequencing;
- d. sequencing the library of oligonucleotides to generate sequencing data;
- and
- e. converting the sequencing data into the form of a bit sequence or byte sequence, wherein the bit sequence or byte sequence is representative of the digital information.
6 more elements
Dependencies are inferred from the claim text.