Image synchronization without input clock and data transmission clock in a pulsed fluorescence imaging system

A system comprising:

• an emitter for emitting pulses of electromagnetic radiation, wherein the emitter comprises a plurality of sources of electromagnetic radiation, wherein the plurality of sources of electromagnetic radiation comprise:
• a visible source that emits a plurality of pulses of a visible wavelength of electromagnetic radiation, and
• an illumination source that emits one or more pulses of electromagnetic radiation comprising a fluorescent excitation wavelength;
• an endoscope comprising an image sensor, wherein the image sensor comprises a pixel array for sensing reflected electromagnetic radiation;
• a plurality of bidirectional data pads in the image sensor for outputting image data and receiving configuration data;
• and
• a controller in electronic communication with the image sensor and the emitter, wherein the controller synchronizes the pulses of electromagnetic radiation emitted by the emitter and the image sensor, such that the image sensor captures data for generating a plurality of exposure frames corresponding to the pulses of electromagnetic radiation emitted by the emitter;
• wherein the illumination source comprises a first fluorescent excitation source and a second fluorescent excitation source, and wherein the first fluorescent excitation source and the second fluorescent excitation source emit different fluorescent excitation wavelength ranges;
• wherein a portion of the plurality of exposure frames comprises a fluorescent excitation frame;
• wherein the controller is configured to adjust a duration, a magnitude, or a duration and a magnitude of the fluorescence excitation wavelength of the illumination source of the emitter during an operational cycle of the image sensor.