Boronic acid appended naphthyl-pyridinium fluorescent saccharide sensors for early detection of gastrointestinal diseases
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsAngel Resendez, Sanjay Malhotra
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Abstract
The present disclosure relates to novel boronic acid receptor compounds and their use in methods of quantifying a saccharide appearing in a sample. Provided are methods of measuring the concentration of a saccharide in a sample as well as methods of measuring the concentration of a halogenated saccharide in a sample. In certain aspects the sample is abiological sample and the methods further include correlating the measured concentration of saccharide in the biological sample to the gastrointestinal permeability in the individual. Disclosed are also kits for performing the above methods.
Claims19
A boronic acid receptor of formula (I):
- wherein:
- is selected from,
- R1 and R2 are independently selected from an alkaryl group, a substituted alkaryl group, an aralkyl group, a substituted aralkyl group, an aryl group, a substituted aryl group, a heteroaryl group, a substituted heteroaryl group, a heteroaryl cation, a substituted heteroaryl cation, heterocycle group, a substituted heterocycle group;
- n and m are independently an integer from 0 to 4;
- and
- X is a counter ion, wherein the number of counter ions is equivalent to the number of cations in the receptor.
Dependencies are inferred from the claim text.