Systems and methods for optimizing engine-aftertreatment system operation

A method for controlling a performance variable of an engine system, the method comprising:

• applying a constraint to a response model that represents a relationship with a manipulated variable or a relationship between the performance variable and the manipulated variable;
• determining a target for the manipulated variable via the response model, wherein the performance variable is indicative of performance of operation of the engine system and the manipulated variable is capable of affecting the performance variable;
• and
• adjusting the operation of the engine system based on the target of the manipulated variable by controlling a fuel system and an air handling system.

A system for controlling a performance variable of an engine system, the system comprising:

• at least one processing circuit structured to:
• apply a constraint to a response model that represents a relationship regarding a manipulated variable or a relationship between the performance variable and the manipulated variable;
• determine a target for the manipulated variable via the response model such that the target of the manipulated variable satisfies the constraint of the response model, wherein the performance variable is indicative of performance of operation of the engine system and the manipulated variable is capable of affecting the performance variable;
• and
• adjust the operation of the engine system based upon the target of the manipulated variable by controlling a fuel system and an air handling system.