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US 11,891,727 B2Granted
Thermally and dimensionally stabilized electrospun compositions and methods of making same
AssigneePoly-Med, Inc.
InventorsMichael Scott Taylor, Seth Dylan McCullen
Life of this patent
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Abstract
Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.
Claims14
A single layer of a dimensionally stable electrospun material comprising:
- a first population of fibers, the first population of fibers being thermally unstable fibers consisting of a poly(glycolic-co-lactic) acid (PGLA) copolymer having a monomer ratio of glycolide from 80 to 95, and lactide of from 20 to 5;
- and
- a second population of fibers, the second population of fibers being thermally stable fibers consisting of a poly(paradioxanone) polymer (PPD);
- wherein the thermally unstable fibers are present in the dimensionally stable electrospun material in an amount of 49% by weight or more;
- wherein the thermally stable fibers are present in the dimensionally stable electrospun material in an amount of from 13 to 49% by weight;
- wherein the thermally unstable fibers are dimensionally unstable at a temperature of about 50° C.;
- wherein the thermally stable fibers are dimensionally stable at a temperature of about 50° C.;
- wherein the first population of fibers and the second population of fibers are distinct and independent from each other;
- wherein the first population of fibers and the second population of fibers are comingled and distributed throughout the dimensionally stable electrospun material;
- and
- wherein the dimensionally stable electrospun material is dimensionally stable at a temperature of about 50° C.
8 more elements
A dimensionally stable electrospun fabric comprising:
- a first population of fibers, the first population of fibers being thermally unstable fibers consisting of a poly(glycolic-co-lactic) acid (PGLA) copolymer having a monomer ratio of glycolide from 80 to 95, and lactide of from 20 to 5;
- a second population of fibers, the second population of fibers being thermally stable fibers consisting of a poly(paradioxanone) polymer (PPD);
- wherein the thermally unstable fibers are present in the dimensionally stable electrospun fabric in an amount of 49% by weight or more;
- wherein the thermally stable fibers are present in the dimensionally stable electrospun fabric in an amount of from 13 to 49% by weight;
- wherein the thermally unstable fibers are dimensionally unstable at a temperature of about 50° C.;
- wherein the thermally stable fibers are dimensionally stable at a temperature of about 50° C.;
- wherein the first population of fibers and the second population of fibers are distinct and independent from each other;
- wherein the first population of fibers and the second population of fibers are comingled and distributed throughout the dimensionally stable electrospun fabric;
- and
- wherein the dimensionally stable electrospun fabric is dimensionally stable at a temperature of about 50° C.
7 more elements
Dependencies are inferred from the claim text.