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US 11,891,665 B2Granted
Compositions for differentiating latent autoimmune diabetes in adults from childhood-onset type 1 diabetes and methods for diagnosing and treating disease
AssigneeThe Children's Hospital of Philadelphia
InventorsStruan Frederick Grant, Rajashree Mishra
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Abstract
Compositions for the identification of patients at risk for the development of latent autoimmune diabetes, and methods of use thereof, for the diagnosis and treatment of the same.
Claims6
A method for treating a subject with an altered risk of Latent autoimmune diabetes (LADA) over Type 1 Diabetes (T1D), the method comprising;
- a) providing a biological sample comprising nucleic acids obtained from a subject having diabetic symptoms;
- b) genotyping said sample for MHC HLA haplotypes HLA-DQB1*0302, HLA-DQB1*0201, HLA-DRB1*1501, HLA-B*3906 and HLA-A*11;
- c) identifying from said genotyping that the said subject lacks HLA-B*3906 and HLA-A*11 biomarkers, absence of said HLA-B*3906 and HLA-A*11 being indicative of an increased risk of LADA over T1D;
- and
- d) after steps b) and c), treating the subject with an agent which modulates LADA symptoms.
2 more elements
Dependencies are inferred from the claim text.