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US 11,891,631 B2Granted
Transcription activator-like effector (tale) - lysine-specific demethylase 1 (LSD1) fusion proteins
AssigneeThe General Hospital Corporation
InventorsJae Keith Joung, Eric M. Mendenhall, Bradley E. Bernstein, Deepak Reyon
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Abstract
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array (TALE) or zinc finger array, and a catalytic domain comprising a sequence that catalyzes histone demethylation, and methods of use thereof.
Claims5
A fusion protein comprising
- an engineered transcription activator-like (TAL) effector repeat array that binds specifically to the nucleic acid sequence set forth in SEQ ID NO:10, and
- a catalytic domain comprising a sequence that catalyzes histone demethylation.
Dependencies are inferred from the claim text.