Generation of neural stem cells from human trophoblast stem cells

A method of treating a neurological disorder in a subject in need thereof, comprising administering at least one neural stem cell to the subject, wherein the at least one neural stem cell is a human neural stem cell that expresses Cdx2, Nanog, Ngn3, RARβ, RXRα, RXRβ, RALDH-2, and RALDH-3 proteins, wherein the neural stem cell has low levels of expression or an absence of expression of CD33 or CD133 cell surface proteins as compared to a human trophoblastic stem cell,

• wherein the neurological disorder is Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, Friedreich's ataxia, Lewy body disease, spinal muscular atrophy, multiple system atrophy, dementia, schizophrenia, paralysis, multiple sclerosis, a spinal cord injury, a brain injury, a cranial nerve disorder, a peripheral sensory neuropathy, epilepsy, a prion disorder, Creutzfeldt-Jakob disease, Alper's disease, cerebellar/spinocerebellar degeneration, Batten disease, corticobasal degeneration, Bell's palsy, Guillain-Barre syndrome, Pick's disease, or autism, and
• wherein administering comprises injecting or implanting.