Back to results
US 11,891,604 B2Granted
Use of miR-18b for prevention, treatment, or diagnosis of muscle disease and neuromuscular disease
AssigneeCuramys Inc.
InventorsJung-Joon Sung, Ki Yoon Kim
Life of this patent
Estimating the term…
Abstract
The present invention relates to use of miR-18b for prevention, treatment, or diagnosis of muscle diseases or neuromuscular diseases, and specifically it was confirmed that, in a muscle disease by gene mutations model, gene mutations reduce miR-18b expression, cause dysregulation of miR-18b signaling pathways, and thus induce calcium signaling, cell differentiation inhibition, and apoptosis. Therefore, miR-18b of the present invention may be used as a target factor for diagnosing and treating muscle diseases caused by gene mutations such as ALS and DMD.
Claims4
A method for treating a muscle disease
- wherein the muscle disease is caused by a SOD1 or a dystrophin gene mutation, the method including:
- administering a composition comprising a pharmaceutically effective amount of miR-18b to a subject, wherein the muscle disease caused by a SOD1 or a dystrophin gene mutation is selected from the group consisting of Duchenne muscular dystrophy, Becker muscular dystrophy, SOD1-associated muscular atrophy, and amyotrophic lateral sclerosis.
Dependencies are inferred from the claim text.