Antibodies to carcinoembryonic antigen-related cell adhesion molecule (CEACAM)
AssigneeFamewave Ltd.
InventorsGal Markel, Tehila Ben Moshe, Yair Sapir, Ilana Mandel, Jacob Schachter, Rona Ortenberg
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Abstract
The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, recognizing a specific epitope of the protein CEACAM1 and optionally binds also other subtypes of the CEACAM protein family Disclosed antibodies and antibody fragments are characterized by specific CDR sequences. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.
Claims20
A chimeric monoclonal antibody or an antibody fragment thereof which recognizes human CEACAM1 comprising (i) a heavy chain variable domain sequence having a sequence set forth in SEQ ID NO:
- 26;
- (ii) a light chain variable domain sequence having a sequence set forth in SEQ ID NO:
- 28;
- and (iii) a set of CDR sequences selected from:
- a set of SEQ ID NOs:
- 13, 14, 15, 16, 17, and 18;
- and a set of SEQ ID NOs:
- 7, 8, 9, 10, 11, and 12.
Dependencies are inferred from the claim text.