Method for treating cancer using CD14 antagonists

A method for treating cancer, comprising:

• administering to a subject in need thereof an effective amount of a CD14 antagonist, wherein the subject is a human subject having cancer;
• wherein the CD14 antagonist is effective in reducing stemness of cancer stem cells (CSCs) in the human subject having cancer;
• wherein the human subject having cancer has an elevated level of CD14, an elevated level of programmed death ligand-1 (PDL1), and an elevated level of CD44, as compared to a control human subject not having cancer;
• wherein the cancer is lung cancer;
• wherein the CD14 antagonist is an anti-CD14 antibody;
• wherein the anti-CD14 antibody is an antigen-binding fragment thereof;
• and
• wherein the anti-CD14 antibody comprises six complementarity determining regions (CDRs) of anti-hCD14-IgA2 antibody, clone D3B8.