Anti-B7-H3 antibody and use thereof

An isolated antibody specifically recognizing B7-H3 or its antigen-binding fragment,

• wherein the antibody or antigen-binding fragment comprises (i) heavy chain complementarity determining regions of CDRH1, CDRH2 and CDRH3, and (ii) light chain complementarity determining regions of CDRL1, CDRL2 and CDRL3, and wherein,
• (a) the CDRH1, CDRH2 and CDRH3 are SEQ ID NOs:
• 1, 5, and 10, respectively, and the CDRL1, CDRL2, and CDRL3 are SEQ ID NOs:
• 15, 20 and 25, respectively;
• (b) the CDRH1, CDRH2 and CDRH3 are SEQ ID NOs:
• 2, 6, and 11, respectively, and the CDRL1, CDRL2, and CDRL3 are SEQ ID NOs:
• 16, 21 and 26, respectively;
• (c) the CDRH1, CDRH2 and CDRH3 are SEQ ID NOs:
• 3, 7, and 12, respectively, and the CDRL1, CDRL2, and CDRL3 are SEQ ID NOs:
• 17, 22 and 27, respectively;
• (d) the CDRH1, CDRH2 and CDRH3 are SEQ ID NOs:
• 1, 8, and 13, respectively, and the CDRL1, CDRL2, and CDRL3 are SEQ ID NOs:
• 18, 23 and 28, respectively;
• (e) the CDRH1, CDRH2 and CDRH3 are SEQ ID NOs:
• 4, 9, and 14, respectively, and the CDRL1, CDRL2, and CDRL3 are SEQ ID NOs:
• 19, 24 and 29, respectively
• (f) the CDRH1, CDRH2 and CDRH3 are SEQ ID NOs:
• 3, 68, and 12, respectively, and the CDRL1, CDRL2, and CDRL3 are SEQ ID NOs:
• 17, 22, and 27, respectively;
• or
• (g) the CDRH1, CDRH2 and CDRH3 are SEQ ID NOs:
• 3, 68, and 12, respectively, and the CDRL1, CDRL2, and CDRL3 are SEQ ID NOs:
• 17, 69, and 27, respectively.