Compositions and methods for treating age-related diseases
AssigneesThe Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans Affairs
InventorsAnton Wyss-Coray, John Vincent Pluvinage, Michael C. Bassik, Michael Haney, Benjamin Smith, Carolyn Bertozzi
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Abstract
Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.
Claims7
A method of treating a neurodegenerative disease comprising:
- exposing one or more of a subject's microglia, macrophage and/or other phagocytic cells to an anti-CD22 antibody wherein said exposing treats said neurodegenerative disease wherein said neurodegenerative disease is Niemann-Pick disease Type C (NPC).
Dependencies are inferred from the claim text.