Antibodies with improved stability to intestinal digestion, polynucleotides thereof and methods of use thereof to treat disease
AssigneeCircle33 LLC
InventorRandall Edward Burton
Life of this patent
Estimating the term…
Abstract
The present invention provides for recombinant antibodies having the features of ruminant early colostrum antibodies that impart resistance to proteases and intestinal digestion. It is a feature of the present invention that when administered to animals including humans, pharmaceutical compositions comprising the novel recombinant antibodies of the present invention, advantageously exhibit resistance to proteases and intestinal digestion. Thus, pharmaceutical compositions of the recombinant antibodies of the invention may be used to deliver antibody therapeutics particularly by oral delivery to the gastrointestinal tract when oral delivery is advantageous.
Claims20
An isolated recombinant monoclonal antibody comprising (a) heavy and light chain CDRs from a non-bovine antibody and (b) a constant region comprising all or a portion of a bovine IgG1 constant region, wherein the constant region or portion thereof comprises all or a portion of a bovine IgG1 hinge region, said all or a portion of the bovine IgG1 hinge region comprising a cluster of three disulfide bonds linking the hinge regions of two heavy chains together, and/or a hinge region amino acid sequence that is less susceptible to common proteases.
Dependencies are inferred from the claim text.