Antibodies and assays for CCL14
AssigneeAstute Medical, Inc.
InventorsRavi A Vijayendran, Hua Wang
Life of this patent
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Abstract
The invention provides CCL14 antibodies.
Claims20
A monoclonal antibody or antigen binding fragment thereof which specifically binds human CCL14, wherein the antibody or antigen binding fragment thereof comprises a heavy chain variable region comprising a CDR1, CDR2, and CDR3 sequence from SEQ ID NO:
- 7, and a light chain variable region comprising a CDR1, CDR2, and CDR3 sequence from SEQ ID NO:
- 8 (10H3/10K1).
A monoclonal antibody or antigen binding fragment thereof comprising a heavy chain variable region comprising a CDR1, CDR2, and CDR3 sequence from SEQ ID NO:
- 7, and a light chain variable region comprising a CDR1, CDR2, and CDR3 sequence from SEQ ID NO:
- 8 (10H3/10K1), wherein the heavy chain variable region has at least 90% sequence similarity within the framework sequences to the framework sequences of SEQ ID NO:
- 7, and the light chain variable region has at least 90% sequence similarity within the framework sequences to the framework sequences of SEQ ID NO:
- 8.
A monoclonal antibody, an antigen binding fragment thereof, an F(ab) fragment thereof, or an F(ab′)2 fragment thereof which comprises a heavy chain variable region comprising sequence from SEQ ID NO:
- 7, and a light chain variable region comprising sequence from SEQ ID NO:
- 8 (10H3/10K1), and which
- a) specifically binds human CCL14, or
- b) binds to an epitope on human CCL14 that comprises all or part of the sequence HSVCTNPSDKWVQDYI (SEQ ID NO:
- 23).
Dependencies are inferred from the claim text.