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US 11,891,436 B2Granted
Monoclonal antibodies to growth and differentiation factor 15 (GDF-15)
AssigneeJulius-Maximilians-UniversitäT WüRzburg
InventorsJörg Wischhusen, Markus Junker, Thomas Müller, Stefan Saremba
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Abstract
The present invention relates to novel monoclonal anti-human-GDF-15 antibodies, pharmaceutical compositions, kits, methods and uses and the cell lines capable of producing the monoclonal antibodies described herein. The present invention further relates to novel antibodies to human GDF-15 capable of inhibiting cancer growth.
Claims13
A method of antagonizing human GDF-15, the method comprising:
- contacting human GDF-15 with an antibody, or an antigen-binding portion thereof, that specifically binds to human GDF-15, wherein the antibody or antigen-binding portion thereof comprises:
- a heavy chain variable domain comprising the heavy chain CDR1, CDR2 and CDR3 amino acid sequences of antibody B1-23;
- and a light chain variable domain comprising the light chain CDR1, CDR2 and CDR3 amino acid sequences of antibody B1-23.
Dependencies are inferred from the claim text.