Thioamide-modified peptides and uses thereof
AssigneesThe Trustees of the University of Pennsylvania, President and Fellows of Harvard College
InventorsE. James Petersson, Alan Saghatelian
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Abstract
The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
Claims6
A method of treating diabetes or obesity in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a thioamide-modified peptide comprising the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.