Yeast cell

A methylotrophic Komagataella yeast comprising an orthologous promoter obtained from a Hansenula yeast cell or a variant of the orthologous promoter, inducible by derepression,

• wherein the orthologous promoter is an orthologous formate dehydrogenase (FMD) promoter comprising the nucleic acid sequence of SEQ ID NO:
• 1, and
• wherein the variant of the orthologous promoter comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO:
• 35, SEQ ID NO:
• 36, SEQ ID NO:
• 37, SEQ ID NO:
• 38, SEQ ID NO:
• 39, SEQ ID NO:
• 40, SEQ ID NO:
• 41, SEQ ID NO:
• 42, SEQ ID NO:
• 43, SEQ ID NO:
• 44, SEQ ID NO:
• 45, SEQ ID NO:
• 46, SEQ ID NO:
• 47, SEQ ID NO:
• 48, SEQ ID NO:
• 49, SEQ ID NO:
• 50, SEQ ID NO:
• 51, SEQ ID NO:
• 52, SEQ ID NO:
• 53, SEQ ID NO:
• 54, SEQ ID NO:
• 55 and SEQ ID NO:
• 56.