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US 11,891,416 B2Granted
Recombinant viral vectors
AssigneeInternational AIDS Vaccine Initiative
InventorsChristopher L. Parks, Ivo Lorenz, Sanjay K. Phogat, Timothy J. Zamb
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Abstract
The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
Claims9
A recombinant vesicular stomatitis virus (VSV) vector comprising a gene encoding an N-terminally truncated form of a VSV surface glycoprotein G (VSV G) (G/Stem), wherein the gene comprises a polynucleotide encoding a polypeptide comprising:
- a transmembrane domain of the VSV G;
- a cytoplasmic tail of the VSV G;
- and
- an ectodomain comprising a stem region of the VSV G,
- wherein the ectodomain, and not the transmembrane domain, comprises one or more human immunodeficiency virus (HIV) epitope.
2 more elements
Dependencies are inferred from the claim text.