Vaccine against Klebsiella pneumoniae

A conjugate of general formula (IV)

• [T*-((—Ux+4—Ux+3—Ux+2—Ux+1—Ux)m—(Vx+2—Vx+1—Vx)1-m)n-T-O-L-E1-W]c-CP (IV)
• wherein
• m is an integer selected from 0 and 1;
• x is 1;
• n is an integer selected from 2, 3, 4, 5, 6, 7, and 8;
• T*- represents H—;
• -L- represents -La-, -La-Le-, -La-Lb-Le-, or -La-Ld-Le-;
• -La- represents —(CH2)o—, —(CH2—CH2—O)o—C2H4—, or —(CH2—CH2—O)o—CH2;
• -Lb- represents —O—, —NH—CO—NH—, —NH—CO—CH2—NH—, —NH—CO—;
• -Ld- represents —(CH2)q—, —(CH(OH))q—, —(CF2)q—, —(CH2—CH2—O)q—C2H4—, or —(CH2—CH2—O)q—CH2—;
• -Le- represents —(CH2)p1—, —(CF2)p1—, —C2H4—(O—CH2—CH2)p1—, —CH2—(O—CH2—CH2)p1— or —(CH2)p1—O—(CH2)p2—;
• and
• o, q, p1 and p2 are independently of each other an integer selected from 1, 2, 3, 4, 5, and 6;
• T represents a bond;
• c is comprised between 2 and 18;
• -E1- represents a covalent bond, —NH—, —O—NH—, —O—, —S—, —CO—, —CH═CH—, —CONH—, —CO—NHNH—,
• —W— is selected from:
• a represents an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10,
• b represents an integer selected from 1, 2, 3 and 4;
• and
• CP is a carrier protein selected from the group consisting of:
• a diphtheria toxoid, a mutated diphtheria toxoid, a modified diphtheria toxoid, a mutated and modified diphtheria toxoid, a tetanus toxoid, a modified tetanus toxoid, a mutated tetanus toxoid, non-lipidated cell-surface liporotein (protein D) of non-typeable Haemophilus influenzae, outer membrane protein (OMP) complex of Neisseria meningitidis, bovine serum albumin (BSA), keyhole limpet hemocyanine (KLH), recombinant non-toxic form of Pseudomonas aeruginosa exotoxin A (rEPA) or cholera toxoid (CT).