Tetrazole derivatives as TRPA1 inhibitors
AssigneeBoehringer Ingelheim International GmbH
InventorsMartin Thomas Fleck, Florian Paul Christian Binder, Jens Willwacher
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Abstract
The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
Claims34
A compound according to formula (I)
- wherein
- A is selected from the group consisting of phenyl, thiophenyl, benzothiophenyl or benzofuranyl, unsubstituted or substituted with one, two or three members of the group R3 consisting of halogen, CN, C1-4-alkyl, O—C1-4-alkyl, C1-4-fluoroalkyl, O—C1-4-fluoroalkyl, C3-4-cycloalkyl, O—C3-4-cycloalkyl, C3-4-cyclofluoroalkyl and O—C3-4-cyclofluoroalkyl,
- or
- A is selected from the group consisting of
- E is selected from the group consisting of O, S, SO, SO2 and CH2;
- and
- R1 and R2 are independently selected from the group consisting of H, C1-4-alkyl, C1-4-fluoroalkyl and halogen,
- or R1 and R2 together with the carbon to which they are attached form a cyclopropyl or cyclobutyl ring;
- or a salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
A compound having the following formula:
A compound having the following formula:
A compound having the following formula:
A compound having the following formula:
A compound having the following formula:
A compound having the following formula:
A compound having the following formula:
A compound having the following formula:
A compound having the following formula:
Dependencies are inferred from the claim text.