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US 11,891,402 B2Granted
Compositions and methods for treating cancer
AssigneeThe Regents of the University of California
InventorsJonathan Ostrem, Ulf Peters, Kevan M. Shokat
Life of this patent
Estimating the term…
Abstract
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
Claims27
A human K-Ras protein having a cysteine at residue 12, wherein said cysteine is covalently bonded to a compound, wherein said compound has the formula
- R1-L1-L2-L3-E,
- wherein
- R1 is substituted or unsubstituted fused ring aryl or substituted or unsubstituted fused ring heteroaryl;
- L1 is a substituted or unsubstituted heteroarylene;
- L2 is a bond;
- L3 is a substituted or unsubstituted spirocyclic linker;
- and, prior to covalently bonding to the cysteine 12,
4 more elements
Dependencies are inferred from the claim text.