Inhibitors of cancer invasion, attachment, and/or metastasis

A compound, or pharmaceutically acceptable salt thereof, having the formula:

• wherein:
• each R1 is independently halogen, —CX13, —CHX12, —CH2X1, —OCX13, —OCH2X1, —OCHX12, —CN, —SOn1R1D, —SOv1NR1AR1B, —NHC(O)NR1AR1B, —N(O)m1, —NR1AR1B, —C(O)R1C, —C(O)—OR1C, —C(O)NR1AR1B, —OR1D, —NR1ASO2R1D, —NR1AC(O)R1C, —NR1AC(O)OR1C, —NR1AOR1C, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or
• two adjacent R1 substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is hydrogen, halogen, —CX23, —CHX22, —CH2X2, —OCX23, —OCH2X2, —OCHX22, —CN, —SOn2R2D, —SOv2NR2AR2B, —NHC(O)NR2AR2B, —N(O)m2, —NR2AR2B, —C(O)R2C, —C(O)—OR2C, —C(O)NR2AR2B, OR2D, —NR2ASO2R2D, —NR2AC(O)R2C, —NR2AC(O)OR2C, —NR2AOR2C, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L1 is a bond, —S(O)2—, —N(R3)—, —O—, —S—, —C(O)—, —C(O)N(R3)—, —N(R3)C(O)—, —N(R3)C(O)NH—, —NHC(O)N(R3)—, —S(O)2N(R3)—, —N(R3)S(O)2—, —C(O)S(O)2N(R3)—, —N(R3)S(O)2C(O)—, —C(O)O—, —OC(O)—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R3 is hydrogen, —CX33, —CHX32, —CH2X3, —CN, —C(O)R3C, —C(O)OR3C, —C(O)NR3AR3B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L2 is a bond, —S(O)2, —N(R4)—, —O—, —S—, —C(O)—, —C(O)N(R4)—, —N(R4)C(O)—, —N(R4)C(O)NH—, —NHC(O)N(R4)—, —S(O)2N(R4)—, —N(R4)S(O)2—,—C(O)S(O)2N(R4)—, —N(R4)S(O)2C(O)—, —C(O)O—, —OC(O)—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R4 is hydrogen, —CX43, —CHX42, —CH2X4, —CN, —C(O)R4C, —C(O)OR4C, —C(O)NR4AR4B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R1A, R1B, R1C, R1D, R2A, R2B, R2C, R2D, R3A, R3B, R3C, R4A, R4B, and R4C are each independently hydrogen, —CX3, —CN, —COOH, —CONH2, —CHX2, —CH2X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or
• R1A and R1B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• or
• R2A and R2B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• or
• R3A and R3B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• or
• R4A and R4B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• X, X1, X2, X3, and X4 are each independently —F, —Cl, —Br, or —I;
• n1 and n2 are independently an integer from 0 to 4;
• m1, m2, v1, and v2 are each independently 1 or 2;
• and
• z1 is an integer from 0 to 4;
• wherein L2—R2 is not hydrogen, —OCH3, —CH3, or —Cl;
• or
• wherein R2 is not
• where
• each R23 is independently halogen, —CX233, —CHX232, —CH2X23, —OCX233, —OCH2X23, —OCHX232, —CN, —SOn23R100D, —SOv23NR100AR100B, —NHC(O)NR100AR100B, —N(O)m23, —NR100AR100B, —C(O)R100C, —C(O)—OR100C, —C(O)NR100AR100B, —OR100D, —NR100ASO2R100D, —NR100AC(O)R100C, —NR100AC(O)OR100C, —NR100AOR100C, N3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or
• two adjacent R23 substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R100A, R100B, R100C, and R100D are each independently hydrogen, —CX3, —CN, —COOH, —CONH2, —CHX2, —CH2X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or
• R100A and R100B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• each X23 is independently —F, —Cl, —Br, or —I;
• each n23 is independently an integer from 0 to 4;
• m23 and v23 are each independently 1 or 2;
• and
• z23 is an integer from 0 to 2.